Solid phase synthesis of 1,3-disubstituted succinimides

被引：10
|
作者：
Alvarez-Gutierrez, JM [1 ]
Nefzi, A [1 ]
Houghten, RA [1 ]
机构：
[1] Torrey Pines Inst Mol Studies, San Diego, CA 92121 USA
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 05期
关键词：
D O I：
10.1016/S0040-4039(99)02166-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The solid phase synthesis of N-substituted succinimides is described. The strategy used is based on the intramolecular cyclization of a dipeptide containing aspartic acid in the second position promoted by diphenylphosphorylazide (DPPA) and triethylamine. Large numbers of succinimides can be prepared using different, commercially available building blocks. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：609 / 612
页数：4
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