Stereoselective Synthesis and Application of β-Amino Ketones

被引：20

作者：

Nguyen, Nghi H. ^{[1
]}

Hughes, Andrew B. ^{[1
]}

Sleebs, Brad E. ^{[2
,3
]}

机构：

[1] La Trobe Univ, Dept Chem, Bundoora, Vic 3086, Australia

[2] Walter & Eliza Hall Inst Med Res, Chem Biol Div, Parkville, Vic 3052, Australia

[3] Univ Melbourne, Dept Med Biol, Melbourne, Vic 3010, Australia

来源：

CURRENT ORGANIC CHEMISTRY | 2014年 / 18卷 / 02期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

beta-amino ketones; amino alcohols; conjugate additions; diastereoselectivity; enantioselectivity; Mannich addition; ASYMMETRIC MANNICH REACTIONS; ENANTIOSELECTIVE CONJUGATE ADDITION; SILOXY SERINE ORGANOCATALYST; PHOSPHONYL IMINE CHEMISTRY; ALPHA; BETA-UNSATURATED KETONES; ALDOL REACTION; DIASTEREOSELECTIVE SYNTHESIS; MULTICOMPONENT SYNTHESIS; 1,3-AMINO ALCOHOLS; CARBONYL-COMPOUNDS;

D O I：

10.2174/138527281802140129104218

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

beta-Amino ketones are of increasing interest owing to their utility as important synthetic precursors in the synthesis of bioactive molecules and natural products. As a result numerous syntheses of beta-amino ketones have emerged in recent years. Of particular signifi-cance are those methods that allow access to stereopure beta-amino ketones. This review highlights recent advances in stereoselective syntheses of beta-amino ketones and also illustrates the importance of beta-amino ketones as useful synthons.

引用

页码：260 / 289

页数：30

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