Clinical implications of E-cadherin associated hereditary diffuse gastric cancer

被引：74
|
作者：
Fitzgerald, RC [1 ]
Caldas, C [1 ]
机构：
[1] Hutchison MRC Res Ctr, Cambridge CB2 2XZ, England
来源：
GUT | 2004年 / 53卷 / 06期
关键词：
D O I：
10.1136/gut.2003.022061
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Approximately 1-3% of gastric cancers arise as a result of inherited gastric cancer predisposition syndromes. These may be of the diffuse or intestinal type. Linkage analysis has recently implicated E-cadherin mutations in an estimated 25% of families with an autosomal dominant predisposition to diffuse type gastric cancers. This subset of gastric cancer has been termed hereditary diffuse gastric cancer (HDGC).
引用
收藏
页码：775 / 778
页数：4
相关论文
共 50 条
  • [31] Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families
    Pharoah, PDP
    Guilford, P
    Caldas, C
    GASTROENTEROLOGY, 2001, 121 (06) : 1348 - 1353
  • [32] Therapeutic targets associated to E-cadherin dysfunction in gastric cancer
    Carneiro, Patricia
    Figueiredo, Joana
    Bordeira-Carrico, Renata
    Fernandes, Maria Sofia
    Carvalho, Joana
    Oliveira, Carla
    Seruca, Raquel
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2013, 17 (10) : 1187 - 1201
  • [33] Clinical criteria revision for hereditary lobular breast cancer associated with E-cadherin germline mutations
    Corso, Giovanni
    De Scalzi, Alessandra
    Feroce, Irene
    Veronesi, Paolo
    Bonanni, Bernardo
    Galimberti, Viviana
    PERSONALIZED MEDICINE, 2018, 15 (03) : 153 - 155
  • [34] Indication for the prophylactic total gastrectomy in the hereditary diffuse gastric cancer in carriers of E-Cadherin mutation. Two observations
    Godlewski, G.
    Chiesa, J.
    Pujol, P.
    Bourgaud, J. F.
    Pignodel, C.
    Prudhomme, M.
    E-MEMOIRES DE L ACADEMIE NATIONALE DE CHIRURGIE, 2007, 6 (01): : 7 - 12
  • [35] Inactivation of the E-cadherin gene in sporadic diffuse-type gastric cancer
    Ascaño, JJ
    Frierson, H
    Moskaluk, CA
    Harper, JC
    Roviello, F
    Jackson, CE
    El-Rifai, W
    Vindigni, C
    Tosi, P
    Powell, SM
    MODERN PATHOLOGY, 2001, 14 (10) : 942 - 949
  • [36] E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer
    Yabuta, T
    Shinmura, K
    Tani, M
    Yamaguchi, S
    Yoshimura, K
    Katai, H
    Nakajima, T
    Mochiki, E
    Tsujinaka, T
    Takami, M
    Hirose, K
    Yamaguchi, A
    Takenoshita, S
    Yokota, J
    INTERNATIONAL JOURNAL OF CANCER, 2002, 101 (05) : 434 - 441
  • [37] Model of the early development of diffuse gastric cancer in E-cadherin mutation carriers and its implications for patient screening
    Carneiro, F
    Huntsman, DG
    Smyrk, TC
    Owen, DA
    Seruca, R
    Pharoah, P
    Caldas, C
    Sobrinho-Simoes, M
    JOURNAL OF PATHOLOGY, 2004, 203 (02): : 681 - 687
  • [38] Clinical evaluation of soluble serum E-cadherin levels in gastric cancer
    Shiozaki, H
    Nakanishi, J
    Gofuku, J
    Oka, H
    Doki, Y
    Tamura, S
    Inoue, M
    Monden, M
    RECENT ADVANCES IN GASTROENTEROLOGICAL CARCINOGENESIS I, 1996, : 981 - 984
  • [39] E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer
    Guilford, PJ
    Hopkins, JBW
    Grady, WM
    Markowitz, SD
    Willis, J
    Lynch, H
    Rajput, A
    Wiesner, GL
    Lindor, NM
    Burgart, LJ
    Toro, TT
    Lee, D
    Limacher, JM
    Shaw, DW
    Findlay, MPN
    Reeve, AE
    HUMAN MUTATION, 1999, 14 (03) : 249 - 255
  • [40] CDH1 truncating mutations in the E-cadherin gene - An indication for total gastrectomy to treat hereditary diffuse gastric cancer
    Norton, Jeffrey A.
    Ham, Christine M.
    Van Dam, Jacques
    Jeffrey, R. Brooke
    Longacre, Teri A.
    Huntsman, David G.
    Chun, Nicki
    Kurian, Allison W.
    Ford, James M.
    ANNALS OF SURGERY, 2007, 245 (06) : 873 - 879
12345