Clinical implications of E-cadherin associated hereditary diffuse gastric cancer

被引：74
|
作者：
Fitzgerald, RC [1 ]
Caldas, C [1 ]
机构：
[1] Hutchison MRC Res Ctr, Cambridge CB2 2XZ, England
来源：
GUT | 2004年 / 53卷 / 06期
关键词：
D O I：
10.1136/gut.2003.022061
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Approximately 1-3% of gastric cancers arise as a result of inherited gastric cancer predisposition syndromes. These may be of the diffuse or intestinal type. Linkage analysis has recently implicated E-cadherin mutations in an estimated 25% of families with an autosomal dominant predisposition to diffuse type gastric cancers. This subset of gastric cancer has been termed hereditary diffuse gastric cancer (HDGC).
引用
收藏
页码：775 / 778
页数：4
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