Photoacoustic angiography for mouse brain cortex using near-infrared light

被引：7
|
作者：
Yang Si-Hua [1 ]
Yin Guang-Zhi [1 ]
机构：
[1] S China Normal Univ, MOE Key Lab Laser Life Sci, Guangzhou 510631, Guangdong, Peoples R China
来源：
ACTA PHYSICA SINICA | 2009年 / 58卷 / 07期
基金：
中国国家自然科学基金;
关键词：
photoacoustic imaging; near-infrared contrast agent; angiography; photoaconstic signal; TOMOGRAPHY; CONTRAST;
D O I：
10.7498/aps.58.4760
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
Photoacoustic imaging is a novel noninvasive imaging technique of biological tissue that overcomes the overwhelming scattering of light in biological tissue by utilizing ultrasonic wave to translate the image signal. In this study, near-infrared light and indocyanine green as an optical contrast agent were used to achieve the cerebrovascular distribution by photoacoustic imaging. Near-infrared light penetrates deep into the brain tissues through the skin and skull, and the indocyanine green enhances the photoacoustic signals of the blood vessels. A photoacoustic angiography of vascular distribution in the mouse brain in vivo was acquired that matches the anatomical photograph well. The experimental result demonstrates the photoacoustic imaging with near-infrared light and optical contrast agent has the potential for functional and molecular biomedical imaging.
引用
收藏
页码：4760 / 4765
页数：6
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