Natural Products: Review for Their Effects of Anti-HBV

被引：12

作者：

Liu, Xuqiang ^{[1
,2
]}

Ma, Changyang ^{[1
]}

Liu, Zhenhua ^{[1
]}

Kang, Wenyi ^{[1
,2
,3
]}

机构：

[1] Henan Univ, Natl R&D Ctr Edible Fungus Proc Technol, Kaifeng 475004, Peoples R China

[2] Funct Food Engn Technol Res Ctr, Kaifeng 475004, Henan, Peoples R China

[3] Henan Univ, Joint Int Res Lab Food & Med Resource Funct, Kaifeng 475004, Henan, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2020年 / 2020卷

关键词：

B VIRUS ACTIVITY; SHIONANE-TYPE TRITERPENES; TRADITIONAL CHINESE HERB; HEPATITIS-B; ACTIVE CONSTITUENTS; CHEMICAL-CONSTITUENTS; ANTIVIRAL DRUGS; REPLICATION; COMPOUND; PROGRESS;

D O I：

10.1155/2020/3972390

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Hepatitis B is a global infectious disease, seriously endangering human health. Currently, there are mainly interferons and nucleoside analogues treatment of hepatitis B in the clinic, which have certain therapeutic effects on hepatitis B, but their side effects and drug resistance are increasingly prominent. Therefore, it is urgently needed to discover and develop new anti-HBV drugs, especially natural products, which have novel, high efficiency, and low toxicity anti-HBV compounds with novel antiviral mechanisms. In this manuscript, the natural products (polysaccharides and 165 compounds) with the activity of antihepatitis B virus are discussed according to their chemical classes, including 14 phenylpropanoids, 8 flavonoids,12 xanthones, 13 anthroquinones, 47 terpenoids, 6 alkaloids, 15 enediynes, 11 aromatics, 18 phenylalanine dipeptides compounds, and 13 others. In addition, the anti-HBV mechanism and targets of natural product were also discussed. The aim of this review is to report new discoveries about anti-HBV natural products and to provide reference for researchers.

引用

页数：24

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