Anti-N-Methyl-D-Aspartate Receptor Encephalitis in Psychiatry

被引：2

作者：

Sakamoto, Shinji ^{[1
]}

Kawai, Hiroki ^{[1
]}

Okahisa, Yuko ^{[1
]}

Tsutsui, Ko ^{[2
]}

Kanbayashi, Takashi ^{[2
]}

Tanaka, Keiko ^{[3
]}

Mizuki, Yutaka ^{[1
]}

Takaki, Manabu ^{[1
]}

Yamada, Norihito ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat, Okayama 7008558, Japan

[2] Akita Univ, Dept Neuropsychiat, Grad Sch Med, Akita 0108543, Japan

[3] Niigata Univ, Brain Res Inst, Dept Anim Model Dev, Niigata 9518585, Japan

来源：

ACTA MEDICA OKAYAMA | 2019年 / 73卷 / 03期

关键词：

NMDAR; encephalitis; psychiatric symptom; schizophrenia; mood disorder; NMDA-RECEPTOR; AUTOIMMUNE-DISEASES; CEREBROSPINAL-FLUID; BIPOLAR DISORDER; ANTIBODIES; SCHIZOPHRENIA; GLUTAMATE; DIAGNOSIS; AUTOANTIBODIES; PREVALENCE;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently-discovered autoimmune disorder in which antibodies target NMDAR in the brain. The number of reported cases of anti-NMDAR encephalitis has increased rapidly. Anti-NMDAR encephalitis can be mistakenly diagnosed as psychiatric disorders because many patients present with prominent psychiatric symptoms and visit psychiatric institutions first. Thus, psychiatrists should cultivate a better understanding of anti-NMDAR encephalitis. In this review, we present the mechanisms, epidemiology, symptoms and clinical course, diagnostic tests, treatment and outcomes of patients with anti-NMDAR encephalitis. Furthermore, we discuss the diversity of clinical spectra of anti-NMDAR encephalitis, and demonstrate a differential diagnosis of psychiatric disease from the perspective of psychiatry.

引用

页码：189 / 195

页数：7

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