Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators

被引：82

作者：

Bemis, Jean E. ^{[1
]}

Vu, Chi B. ^{[1
]}

Xie, Roger ^{[1
]}

Nunes, Joseph J. ^{[1
]}

Ng, Pui Yee ^{[1
]}

Disch, Jeremy S. ^{[1
]}

Milne, Jill C. ^{[1
]}

Carney, David P. ^{[1
]}

Lynch, Amy V. ^{[1
]}

Jin, Lei ^{[1
]}

Smith, Jesse J. ^{[1
]}

Lavu, Siva ^{[1
]}

Iffland, Andre ^{[1
]}

Jirousek, Michael R. ^{[1
]}

Perni, Robert B. ^{[1
]}

机构：

[1] A GSK Co, Sirtris, Cambridge, MA 01239 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 08期

关键词：

Sirtuins; SIRT1; activator; CALORIE RESTRICTION;

D O I：

10.1016/j.bmcl.2008.11.106

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

SIRT1 is an NAD(+)-dependent protein deacetylase that appears to produce beneficial effects on metabolic parameters such as glucose and insulin homeostasis. Activation of SIRT1 by resveratrol ( 1) has been shown to modulate insulin resistance, increase mitochondrial content and prolong survival in lower organisms and in mice on a high fat diet. Herein, we describe the identification and SAR of a series of oxazolo[4,5-b]pyridines as novel small molecule activators of SIRT1 which are structurally unrelated to and more potent than resveratrol. (C) 2009 Published by Elsevier Ltd.

引用

页码：2350 / 2353

页数：4

共 50 条

[21] SYNTHESIS OF SOME NOVEL THIAZOLO[4,5-b]PYRIDINES AND THEIR TUBERCULOSTATIC ACTIVITY EVALUATION
Chaban, Taras
Klenina, Olena
Drapak, Iryna
Ogurtsov, Volodymyr
Chaban, Igor
Novikov, Volodymyr
CHEMISTRY & CHEMICAL TECHNOLOGY, 2014, 8 (03): : 287 - 292
[22] 1,3-Dibromo-5,5-dimethylhydantoin as an efficient homogeneous catalyst for synthesis of benzoxazoles, benzimidazoles, and oxazolo[4,5-b]pyridines
Hojati, Seyedeh Fatemeh
Maleki, Behrooz
Beykzadeh, Zahra
MONATSHEFTE FUR CHEMIE, 2011, 142 (01): : 87 - 91
[23] 2-(SUBSTITUTED PHENYL)OXAZOLO[4,5-B]PYRIDINES AND 2-(SUBSTITUTED PHENYL)OXAZOLO[5,4-B]PYRIDINES AS NON-ACIDIC ANTI-INFLAMMATORY AGENTS
CLARK, RL
PESSOLANO, AA
WITZEL, B
LANZA, T
SHEN, TY
VANARMAN, CG
RISLEY, EA
JOURNAL OF MEDICINAL CHEMISTRY, 1978, 21 (11) : 1158 - 1162
[24] 2-Aryl-benzimidazole-4-carboxamides as novel SIRT1 activators
Disch, Jeremy S.
Vu, Chi B.
McPherson, Lauren
Ng, Pui Yee
Bemis, Jean E.
Carney, David P.
Lynch, Amy V.
Loh, Christine
Ribich, Scott
Romero, Peggy
Smith, Jesse J.
Song, Jeffrey
Gagne, David J.
Cote, Angela
Davis, Meghan
Lainez, Elden
Perni, Robert B.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 240
[25] Discovery of Novel Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A)
Hu, Essa
Andrews, Kristin
Chmait, Samer
Zhao, Xiaoning
Davis, Carl
Miller, Silke
Della Puppa, Geraldine Hill
Dovlatyan, Mary
Chen, Hang
Lester-Zeiner, Dianna
Able, Jessica
Biorn, Christopher
Ma, Ji
Shi, Jianxia
Treanor, James
Allen, Jennifer R.
ACS MEDICINAL CHEMISTRY LETTERS, 2014, 5 (06): : 700 - 705
[26] THE SYNTHESIS AND THE STRUCTURE-ACTIVITY-RELATIONSHIPS OF SOME SUBSTITUTED BENZOXAZOLES, OXAZOLO(4,5-B)PYRIDINES, BENZOTHIAZOLES AND BENZIMIDAZOLES AS ANTIMICROBIAL AGENTS
YALCIN, I
OREN, I
SENER, E
AKIN, A
UCARTURK, N
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1992, 27 (04) : 401 - 406
[27] 3-[(3'-hydroxymethyl)-4'-hydroxybutyl]imidazo[4,5-b]pyridines - Novel antiviral agents
Cundy, DJ
Holan, G
Otaegui, M
Simpson, GW
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (06) : 669 - 674
[28] TETRAZOLO[1,5-A]PYRIDINES AND FURAZANO[4,5-B]PYRIDINE 1-OXIDES
LOWEMA, CK
NISSAN, RA
WILSON, WS
JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (12): : 3755 - 3761
[29] Silica sulfuric acid catalyzed synthesis of benzoxazoles, benzimidazoles and oxazolo[4,5-b]pyridines under heterogeneous and solvent-free conditions
I. Mohammadpoor-Baltork
M. Moghadam
S. Tangestaninejad
V. Mirkhani
M. A. Zolfigol
S. F. Hojati
Journal of the Iranian Chemical Society, 2008, 5 : S65 - S70
[30] Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases
Knutson, Mitchell D.
Leeuwenburgh, Christiaan
NUTRITION REVIEWS, 2008, 66 (10) : 591 - 596

← 1 2 3 4 5 →