Coptisine suppresses proliferation and inhibits metastasis in human pancreatic cancer PANC-1 cells

被引：15
|
作者：
Ya-Li Zhang [1 ]
Zhang, Xiao [1 ]
Miao, Xiang-Zhen [1 ]
Yuan, Yan-Yan [1 ]
Gao, Jian [1 ]
Li, Xia [2 ]
Liu, Yong-Gang [1 ]
Tan, Peng [1 ]
机构：
[1] Beijing Univ Chinese Med, Sch Chinese Mat Mad, Beijing 100029, Peoples R China
[2] Chinese Acad Sci, Inst Genet & Dev Biol, Beijing 100101, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2020年 / 22卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Pancreatic cancer; coptisine; PANC-1; cell; PROTEIN-KINASE CASCADE; TUMOR-GROWTH; IN-VITRO; ADENOCARCINOMA; STATISTICS;
D O I：
10.1080/10286020.2019.1585820
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The effects of coptisine against advanced stage of human pancreatic carcinoma PANC-1 cells was investigated in vitro. Coptisine (25-150 mu M) treatment for 48 h caused dose-dependent cell growth inhibition by using CCK-8 assay. Additionally, coptisine was found to inhibit PANC-1 cells metastasis by the wound healing assay. Flow cytometry data indicated that coptisine (25-100 mu M) exhibited dose-dependent G1 phase arrest and moderate reduction of S phase. Coptisine was also found to inhibit ERK phosphorylation and total ERK levels. Our research suggested that coptisine would be a potential therapeutic drug for the treatment of pancreatic cancer. [GRAPHICS] .
引用
收藏
页码：452 / 463
页数：12
相关论文
共 50 条
  • [31] LY294002 Enhances Inhibitory Effect of Gemcitabine on Proliferation of Human Pancreatic Carcinoma PANC-1 Cells
    柯晓煜
    王渝
    谢祚启
    刘志清
    张翠芳
    赵秋
    杨东亮
    Current Medical Science, 2013, (01) : 57 - 62
  • [32] LY294002 Enhances Inhibitory Effect of Gemcitabine on Proliferation of Human Pancreatic Carcinoma PANC-1 Cells
    柯晓煜
    王渝
    谢祚启
    刘志清
    张翠芳
    赵秋
    杨东亮
    Journal of Huazhong University of Science and Technology(Medical Sciences), 2013, 33 (01) : 57 - 62
  • [33] Effects of disulfiram on apoptosis in PANC-1 human pancreatic cancer cell line
    Dastjerdi, M. Nikbakht
    Babazadeh, Z.
    Rabbani, M.
    Gharagozloo, M.
    Esmaeili, A.
    Narimani, M.
    RESEARCH IN PHARMACEUTICAL SCIENCES, 2014, 9 (04) : 287 - 294
  • [34] Cytotoxic effect of pyocyanin on human pancreatic cancer cell line (Panc-1)
    Moayedi, Aylin
    Nowroozi, Jamileh
    Sepahy, Abbas Akhavan
    IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2018, 21 (08) : 794 - 799
  • [35] RAGE upregulation confers a proliferative phenotype to PANC-1 pancreatic cancer cells
    Swami, Priyanka
    Vetter, Stefan W.
    Leclerc, Estelle
    FASEB JOURNAL, 2017, 31
  • [36] Metabolic characterization of invaded cells of the pancreatic cancer cell line, PANC-1
    Fujita, Mayumi
    Imadome, Kaori
    Imai, Takashi
    CANCER SCIENCE, 2017, 108 (05): : 961 - 971
  • [37] Investigation of Juglone's apoptotic effect on PANC-1 pancreatic cancer cells
    Asik, Aycan
    Arikoglu, Hilal
    Dursunoglu, Duygu
    Menevse, Esma
    ANTI-CANCER DRUGS, 2015, 26 : E37 - E38
  • [38] Study on the Constituents of Mexican Propolis and Their Cytotoxic Activity against PANC-1 Human Pancreatic Cancer Cells
    Li, Feng
    Awale, Suresh
    Tezuka, Yasuhiro
    Esmi, Hiroyasu
    Kadota, Shigetoshi
    JOURNAL OF NATURAL PRODUCTS, 2010, 73 (04): : 623 - 627
  • [39] Diarylheptanoids suppress proliferation of pancreatic cancer PANC-1 cells through modulating shh-Gli-FoxM1 pathway
    Dong, Guang-zhi
    Jeong, Ji Hye
    Lee, Yu-ih
    Lee, So Yoon
    Zhao, Hui-Yuan
    Jeon, Raok
    Lee, Hwa Jin
    Ryu, Jae-Ha
    ARCHIVES OF PHARMACAL RESEARCH, 2017, 40 (04) : 509 - 517
  • [40] Diarylheptanoids suppress proliferation of pancreatic cancer PANC-1 cells through modulating shh-Gli-FoxM1 pathway
    Guang-zhi Dong
    Ji Hye Jeong
    Yu-ih Lee
    So Yoon Lee
    Hui-Yuan Zhao
    Raok Jeon
    Hwa Jin Lee
    Jae-Ha Ryu
    Archives of Pharmacal Research, 2017, 40 : 509 - 517
12345