Diacylglycerol kinase;
Nuclear factor-kappa B;
Tumor necrosis factor-alpha;
Phosphorylation;
Protein kinase C zeta;
ACTIVATION;
CELLS;
P65;
D O I:
10.1016/j.febslet.2009.09.017
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
We recently reported that diacylglycerol kinase (DGK) alpha enhanced tumor necrosis factor-alpha (TNF-alpha)-induced activation of nuclear factor-kappa B (NF-kappa B). However, the signaling pathway between DGK alpha and NF-kappa B remains unclear. Here, we found that small interfering RNA-mediated knockdown of DGK alpha strongly attenuated protein kinase C (PKC) zeta-dependent phosphorylation of a large subunit of NF-kappa B, p65/RelA, at Ser311 but not PKC zeta-independent phosphorylation at Ser468 or Ser536. Moreover, knockdown and overexpression of PKC zeta suppressed and synergistically enhanced DGK alpha-mediated NF-kappa B activation, respectively. These results strongly suggest that DGKa positively regulates TNF-alpha-dependent NF-kappa B activation via the PKC zeta-mediated Ser311 phosphorylation of p65/RelA. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
机构:
Chinese Acad Med Sci, Inst Med Biotechnol, Beijing, Peoples R China
Peking Union Med Coll, Beijing, Peoples R China
Qingdao Univ, Qingdao Women & Childrens Hosp, Qingdao, Peoples R ChinaChinese Acad Med Sci, Inst Med Biotechnol, Beijing, Peoples R China
Liu, Lu
Liu, Yang
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h-index: 0
机构:
Chinese Acad Med Sci, Inst Med Biotechnol, Beijing, Peoples R China
Peking Union Med Coll, Beijing, Peoples R ChinaChinese Acad Med Sci, Inst Med Biotechnol, Beijing, Peoples R China
Liu, Yang
Liu, Xiaojia
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Inst Med Biotechnol, Beijing, Peoples R China
Peking Union Med Coll, Beijing, Peoples R ChinaChinese Acad Med Sci, Inst Med Biotechnol, Beijing, Peoples R China
Liu, Xiaojia
Zhang, Na
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Inst Med Biotechnol, Beijing, Peoples R China
Peking Union Med Coll, Beijing, Peoples R ChinaChinese Acad Med Sci, Inst Med Biotechnol, Beijing, Peoples R China
Zhang, Na
Mao, Genxiang
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h-index: 0
机构:
Zhejiang Hosp, Dept Geriatr, Zhejiang Prov Key Lab Geriatr, Hangzhou, Zhejiang, Peoples R ChinaChinese Acad Med Sci, Inst Med Biotechnol, Beijing, Peoples R China
Mao, Genxiang
Zeng, Qingxuan
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h-index: 0
机构:
Chinese Acad Med Sci, Inst Med Biotechnol, Beijing, Peoples R China
Peking Union Med Coll, Beijing, Peoples R ChinaChinese Acad Med Sci, Inst Med Biotechnol, Beijing, Peoples R China
Zeng, Qingxuan
Yin, Mingxiao
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Inst Med Biotechnol, Beijing, Peoples R China
Peking Union Med Coll, Beijing, Peoples R ChinaChinese Acad Med Sci, Inst Med Biotechnol, Beijing, Peoples R China
Yin, Mingxiao
Song, Danqing
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Inst Med Biotechnol, Beijing, Peoples R China
Peking Union Med Coll, Beijing, Peoples R ChinaChinese Acad Med Sci, Inst Med Biotechnol, Beijing, Peoples R China
Song, Danqing
Deng, Hongbin
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Inst Med Biotechnol, Beijing, Peoples R China
Peking Union Med Coll, Beijing, Peoples R ChinaChinese Acad Med Sci, Inst Med Biotechnol, Beijing, Peoples R China