Homophilic NCAM interactions interfere with L1 stimulated neurite outgrowth

被引：13
|
作者：
Kristiansen, LV [1 ]
Marques, FA [1 ]
Soroka, V [1 ]
Ronn, LCB [1 ]
Kiselyov, V [1 ]
Pedersen, N [1 ]
Berezin, V [1 ]
Bock, E [1 ]
机构：
[1] Univ Copenhagen, Panum Inst, Prot Lab, Inst Mol Pathol, DK-2200 Copenhagen N, Denmark
来源：
FEBS LETTERS | 1999年 / 464卷 / 1-2期
关键词：
cell adhesion; neurite outgrowth; L1; NCAM; interaction; Ig-module;
D O I：
10.1016/S0014-5793(99)01671-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cell adhesion molecules NCAM and L1 are considered to play key roles in neuronal development and plasticity. L1 has been shown to interact with NCAM, possibly through NCAM binding to oligomannosidic glycans present in L1, We investigated the effect of recombinant immunoglobulin (Ig) modules of NCA-IM involved in homophilic NCAM binding, on L1 induced neurite outgrowth from PC12-E2 cells and found a complete inhibition of L1 induced neurite outgrowth after addition of Ig-modules 1, 2 and 3 of NCAM, suggesting that the ligation state of NCAM is crucial for normal L1 signaling. (C) 1999 Federation of European Biochemical Societies.
引用
收藏
页码：30 / 34
页数：5
相关论文
共 50 条
  • [21] Chlorhexidine inhibits L1 cell adhesion molecule–mediated neurite outgrowth in vitro
    Aaron M. Milstone
    Penny Bamford
    Susan W. Aucott
    Ningfeng Tang
    Kimberly R. White
    Cynthia F. Bearer
    Pediatric Research, 2014, 75 : 8 - 13
  • [22] The role of the cytoplasmic domain of the neural cell adhesion molecule L1 in neurite outgrowth
    Shibayama, Y
    Lee, S
    Lemmon, V
    Takeda, Y
    Yamada, K
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, 94 : 191P - 191P
  • [23] The close homologue of the neural adhesion molecule L1 (CHL1): patterns of expression and promotion of neurite outgrowth by heterophilic interactions
    Hillenbrand, R
    Molthagen, M
    Montag, D
    Schachner, M
    EUROPEAN JOURNAL OF NEUROSCIENCE, 1999, 11 (03) : 813 - 826
  • [24] Chlorhexidine inhibits L1 cell adhesion molecule-mediated neurite outgrowth in vitro
    Milstone, Aaron M.
    Bannford, Penny
    Aucott, Susan W.
    Tang, Ningfeng
    White, Kimberly R.
    Bearer, Cynthia F.
    PEDIATRIC RESEARCH, 2014, 75 (01) : 8 - 13
  • [25] The Promotive Effects of Thymosin β4 on Neuronal Survival and Neurite Outgrowth by Upregulating L1 Expression
    Hao Yang
    Xipeng Cheng
    Qing Yao
    Jingwen Li
    Gong Ju
    Neurochemical Research, 2008, 33
  • [26] Critical and optimal Ig domains for promotion of neurite outgrowth by L1/Ng-CAM
    Haspel, J
    Friedlander, DR
    Ivgy-May, N
    Chickramane, S
    Roonprapunt, C
    Chen, SZ
    Schachner, M
    Grumet, M
    JOURNAL OF NEUROBIOLOGY, 2000, 42 (03): : 287 - 302
  • [27] The promotive effects of thymosin β4 on neuronal survival and neurite outgrowth by upregulating L1 expression
    Yang, Hao
    Cheng, Xipeng
    Yao, Qing
    Li, Jingwen
    Ju, Gong
    NEUROCHEMICAL RESEARCH, 2008, 33 (11) : 2269 - 2280
  • [28] Enhancement of neurite outgrowth by the soluble form of human L1 (neural cell adhesion molecule)
    Sugawa, M
    Ono, K
    Yasui, Y
    Kishi, T
    Tsumori, T
    NEUROREPORT, 1997, 8 (14) : 3157 - 3162
  • [29] THE 4TH IMMUNOGLOBULIN-LIKE DOMAIN OF NCAM CONTAINS A CARBOHYDRATE-RECOGNITION DOMAIN FOR OLIGOMANNOSIDIC GLYCANS IMPLICATED IN ASSOCIATION WITH L1 AND NEURITE OUTGROWTH
    HORSTKORTE, R
    SCHACHNER, M
    MAGYAR, JP
    VORHERR, T
    SCHMITZ, B
    JOURNAL OF CELL BIOLOGY, 1993, 121 (06): : 1409 - 1421
  • [30] NEURITE OUTGROWTH STIMULATED BY L1 REQUIRES CALCIUM INFLUX INTO NEURONS BUT IS NOT ASSOCIATED WITH CHANGES IN STEADY-STATE LEVELS OF CALCIUM IN GROWTH CONES
    HARPER, SJ
    BOLSOVER, SR
    WALSH, FS
    DOHERTY, P
    CELL ADHESION AND COMMUNICATION, 1994, 2 (05) : 441 - 453
12345