Phylogenetic and genetic characterization of Treponema pallidum strains from syphilis patients in Japan by whole-genome sequence analysis from global perspectives

被引:11
|
作者
Nishiki, Shingo [1 ,2 ]
Lee, Kenichi [1 ]
Kanai, Mizue [1 ,3 ]
Nakayama, Shu-ichi [1 ]
Ohnishi, Makoto [1 ]
机构
[1] Natl Inst Infect Dis, Dept Bacteriol 1, Shinjuku Ku, 1-23-1 Toyama, Tokyo 1628640, Japan
[2] Tottori Univ, Grad Sch Med, Dept Social Med, Div Environm & Prevent Med, 86 Nishi Machi, Yonago, Tottori 6838503, Japan
[3] Osaka City Publ Hlth Off, Abeno Ku, 1-2-7-1,000 Asahi Cho, Osaka, Osaka 5450051, Japan
关键词
MACROLIDE RESISTANCE; EPIDEMIOLOGY; EMERGENCE; ALGORITHM; ORIGIN;
D O I
10.1038/s41598-021-82337-7
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Japan has had a substantial increase in syphilis cases since 2013. However, research on the genomic features of the Treponema pallidum subspecies pallidum (TPA) strains from these cases has been limited. Here, we elucidated the genetic variations and relationships between TPA strains in Japan (detected between 2014 and 2018) and other countries by whole-genome sequencing and phylogenetic analyses, including syphilis epidemiological surveillance data and information on patient sexual orientation. Seventeen of the 20 strains in Japan were SS14- and the remaining 3 were Nichols-lineage. Sixteen of the 17 SS14-lineage strains were classified into previously reported Sub-lineage 1B. Sub-lineage 1B strains in Japan have formed distinct sub-clusters of strains from heterosexuals and strains from men who have sex with men. These strains were closely related to reported TPA strains in China, forming an East-Asian cluster. However, those strains in these countries evolved independently after diverging from their most recent common ancestor and expanded their genetic diversity during the time of syphilis outbreak in each country. The genetic difference between the TPA strains in these countries was characterized by single-nucleotide-polymorphism analyses of their penicillin binding protein genes. Taken together, our results elucidated the detailed phylogenetic features and transmission networks of syphilis.
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页数:10
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