Neurochemical mechanisms underlying alcohol addiction: Model experiments on rats

被引:0
|
作者
Kharchenko, NK
Synytsky, VN
机构
[1] Minist Publ Hlth Ukraine, Interdepartmental Ctr Clin & Expt Narcol, Kiev, Ukraine
[2] Natl Acad Sci Ukraine, Ukrainian Inst Social & Legal Psychiat & Narcol, Kiev, Ukraine
关键词
alcohol addiction; ethanol; acetaldehyde; alcohol dehydrogenase; aldehyde dehydrogenase; catecholamines; hypothalamus; midbrain; neocortex; blood;
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We measured the activities of the main alcohol-metabolizing enzymes (alcohol dehydrogenase, AlDH, and aldehyde dehydrogenase, AdhDH) in the blood serum, comparing these indices with the contents of ethanol and its main metabolite, acetaldehyde (AcAdh), in the blood, and also measured the contents of catecholamines (adrenaline, noradrenaline,, and dopamine) in the blood and in different brain structures (hypothalamus, midbrain, and neocortex) of rats in the states of acute alcohol intoxication and chronic alcohol addiction. It was shown that, because of dissimilar changes in the activities of AlDH and AdhDH under conditions of alcohol intoxication, the dynamic balance between endogenous ethanol and AcAdh existing in the norm is disturbed, which results in an increase in the level of AcAdh. Such a phenomenon probably is one of the crucial factors underlying the development of alcohol addiction.
引用
收藏
页码:35 / 43
页数:9
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