Calcitonin gene-related peptide (CGRP) antagonists: blockers of neuronal transmission in migraine

被引：23
|
作者：
Brain, SD [1 ]
机构：
[1] Kings Coll London, Ctr Cardiovasc Biol & Med, London SE1 1UL, England
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 2004年 / 142卷 / 07期
关键词：
CGRP; BIBN4096BS; migraine;
D O I：
10.1038/sj.bjp.0705806
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The neuropeptide calcitonin gene-related peptide (CGRP) is a potent vasodilator that is contained in and released from sensory nerves. CGRP has been implicated in migraine, and the nonpeptide CGRP antagonist BIBN4096BS has been shown to be effective in clinical trials in migraine. To date, it has been largely assumed that the CGRP antagonist is effective due to its ability to block vasodilator activity. Goadsby and co-workers present data that now suggest that CGRP antagonists may also block neuronal transmission in migraine.
引用
收藏
页码：1053 / 1054
页数：2
相关论文
共 50 条
  • [21] Non-peptide calcitonin gene-related peptide (CGRP) receptor antagonists.
    Daines, RA
    Sham, KKC
    Taggart, JJ
    Kingsbury, WD
    Chan, J
    Breen, A
    Disa, J
    Aiyar, N
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 214 : 237 - MEDI
  • [22] Calcitonin gene-related peptide and migraine
    Ruth Kirby
    Nature Clinical Practice Neurology, 2006, 2 (1): : 5 - 5
  • [23] Calcitonin gene-related peptide and migraine
    Karsan, Nazia
    Goadsby, Peter J.
    CURRENT OPINION IN NEUROLOGY, 2015, 28 (03) : 250 - 254
  • [24] Calcitonin Gene-Related Peptide (CGRP) and Migraine Current Understanding and State of Development
    Bigal, Marcelo E.
    Walter, Sarah
    Rapoport, Alan M.
    HEADACHE, 2013, 53 (08): : 1230 - 1244
  • [25] Rimegepant Calcitonin gene-related peptide (CGRP) receptor antagonist Treatment of migraine
    Lionetto, L.
    Capi, M.
    Curto, M.
    Cipolla, F.
    Guglielmetti, M.
    Martelletti, P.
    DRUGS OF THE FUTURE, 2019, 44 (08) : 635 - 642
  • [26] Zavegepant Calcitonin gene-related peptide (CGRP) receptor antagonist Treatment of migraine
    Cipolla, F.
    Capi, M.
    Lionetto, L.
    De Bernardini, D.
    De Angelis, V
    Martelletti, P.
    DRUGS OF THE FUTURE, 2021, 46 (04) : 281 - 288
  • [27] Calcitonin gene-related peptide (CGRP) receptor antagonists: Novel aspartates and succinates
    Luo, Guanglin
    Chen, Ling
    Pin, Sokhom S.
    Xu, Cen
    Conway, Charles M.
    Macor, John E.
    Dubowchik, Gene M.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (08) : 2912 - 2916
  • [28] Ubrogepant Calcitonin gene-related peptide (CGRP) receptor antagonist Treatment of migraine
    Gras, J.
    DRUGS OF THE FUTURE, 2019, 44 (11) : 869 - 879
  • [29] Pathophysiological role of calcitonin gene-related peptide (CGRP) in migraine and cluster headache
    Messlinger, Karl
    SCHMERZ, 2020, 34 (02): : 181 - 187
  • [30] Calcitonin gene-related peptide (CGRP): role in migraine pathophysiology and therapeutic targeting
    Wattiez, Anne-Sophie
    Sowers, Levi P.
    Russo, Andrew F.
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2020, 24 (02) : 91 - 100
12345