An analytical method for the determination of perfluorinated compounds in whole blood using acetonitrile and solid phase extraction methods

被引：59
|
作者：
Yeung, Leo W. Y. [1 ,2 ]
Taniyasu, Sachi [1 ]
Kannan, Kurunthachalam [3 ,4 ]
Xu, Della Z. Y. [2 ]
Guruge, Keerthi S. [5 ]
Lam, Paul K. S. [2 ]
Yamashita, Nobuyoshi [1 ]
机构：
[1] Natl Inst Adv Ind Sci & Technol, Tsukuba, Ibaraki 3058569, Japan
[2] City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China
[3] SUNY Albany, Wadsworth Ctr, New York State Dept Hlth, Albany, NY 12201 USA
[4] SUNY Albany, Dept Environm Hlth Sci, Albany, NY 12201 USA
[5] Natl Inst Anim Hlth, Safety Res Team, Tsukuba, Ibaraki 3050856, Japan
来源：
JOURNAL OF CHROMATOGRAPHY A | 2009年 / 1216卷 / 25期
关键词：
Whole blood; Acetonitrile; Solid phase extraction; Formic acid; Taurodeoxycholic acid; Perfluorooctanesulfonate; TANDEM MASS-SPECTROMETRY; PERFLUOROOCTANE SULFONATE; ORGANIC FLUORINE; SOUTH CHINA; HUMAN SERUM; SHORT-CHAIN; ACIDS; FLUOROCHEMICALS; MATRICES; SAMPLES;
D O I：
10.1016/j.chroma.2009.04.070
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A method for the analysis of perfluorinated compounds (perfluoroalkyl sulfonates: C4, C6, C8, C10; perfluoroalkyl sulfinates: C6, C8, C10; perfluorooctanesulfonamide, N-ethyl perfluorooctanesulfonamide, N-ethyl perfluorooctanesulfonamidoacetate, perfluorocarboxylates: C4-C14; fluorotelomer carboxylate (7:3, 8:2) in whole blood using acetonitrile and OASIS WAX (R) solid phase extraction (SPE) cartridge was developed. Separation of target compounds in two HPLC columns (ion exchange JJ50-2D and C18 Betasil columns) was examined. Matrix recoveries of the developed methods ranged from 70% to 120%. Separation of possible inferences Such as taurodeoxycholic acid (TDC) was accomplished using an ion exchange JJ50-2D column, and this separation was validated using whole blood of different animals. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：4950 / 4956
页数：7
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