Residence time distribution of a pharmaceutical grade polymer melt in a single screw extrusion process

被引：43
|
作者：
Nikitine, Clemence [1 ,2 ]
Rodier, Elisabeth [1 ]
Sauceau, Martial [1 ]
Fages, Jacques [1 ]
机构：
[1] Univ Toulouse, Ctr RAPSODEE, UMR 2392, CNRS,Ecole Mines Albi, F-81013 Albi, France
[2] CNRS CPE, UMR, LGPC, Lyon, France
来源：
CHEMICAL ENGINEERING RESEARCH & DESIGN | 2009年 / 87卷 / 6A期
关键词：
Extrusion; Polymer; Eudragit E100; Supercritical carbon dioxide; Residence time distribution; CARBON-DIOXIDE; EXTRUDERS; ELEMENT;
D O I：
10.1016/j.cherd.2008.10.008
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
The residence time distribution (RTD) of a flowing polymer through a single screw extruder was studied. This extruder allows injecting supercritical carbon dioxide (scCO(2)) used as physical foaming agent. The tested material is Eudragit E100, a pharmaceutical polymer. RTD was measured at various operating conditions and a model describing RTD has been developed. High screw speed or high temperature implies short residence time, but these parameters do not have the same effect on polymer flow. In the flow rate range studied, scCO(2) has no significant influence. A mathematical model consisting of a plug flow reactor in series with a continuous stirred tank reactor (CSTR) cross-flowing with a dead volume fitted well the experimental data. (C) 2008 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：809 / 816
页数：8
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