Synthesis and biological evaluation of novel quinolin-2(1H)-one derivatives as potential antimicrobial agents

被引：8

作者：

Deng, Qiao ^{[1
]}

Ji, Qing-Gang ^{[1
]}

Ge, Zhi-Qiang ^{[1
]}

Liu, Xiao-Fei ^{[1
]}

Yang, Dan ^{[1
]}

Yuan, Lv-Jiang ^{[1
]}

机构：

[1] Southwest Univ, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China

来源：

MEDICINAL CHEMISTRY RESEARCH | 2014年 / 23卷 / 12期

关键词：

Quinolin-2(1H)-one; L-Alanine ester; Amide; Antibacterial; Antifungal; BAD BUGS; CHALLENGES; DRUGS;

D O I：

10.1007/s00044-014-1107-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel quinolin-2(1H)-one derivatives were synthesized and characterized by IR, H-1 NMR, C-13 NMR, and MS spectral data. All the new compounds were screened for their antimicrobial activities against six trains of bacteria and five fungi in vitro by twofold serial dilution technique. The bioactive assay showed that most of the compounds exhibited moderate to good antimicrobial activities in comparison with the streptomycin, especially, compound 6a, the fluoro-substituted aromatic amide derivative, showed good antibacterial activities against B.proteus and P.aeruginosa with minimal inhibitory concentration value of 32 and 16 mu g/ml, respectively.

引用

页码：5224 / 5236

页数：13

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