Sorafenib Therapy for Pediatric Acute Myeloid Leukemia with FMS-like Tyrosine Kinase 3-internal Tandem Duplication Mutations: 2 Case Reports

被引：1
|
作者：
Osone, Shinya [1 ]
Imamura, Toshihiko [1 ]
Kanayama, Takuyo [1 ,2 ]
Tsuma, Yusuke [1 ]
Kawashima-Goto, Sachiko [1 ]
Nakatani, Takuya [1 ]
Sugimoto, Atsuya [1 ]
Takai, Akari [1 ]
Miyachi, Mitsuru [1 ]
Tamura, Shinichi [2 ]
Ishida, Hiroyuki [1 ,2 ]
Hosoi, Hajime [1 ]
机构：
[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Pediat, Kyoto, Japan
[2] Matsushita Mem Hosp, Dept Pediat, Moriguchi, Osaka, Japan
来源：
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2017年 / 39卷 / 04期
关键词：
acute myeloid leukemia; sorafenib; FLT3-ITD; stem cell transplantation; children; STEM-CELL TRANSPLANTATION; MULTIKINASE INHIBITOR SORAFENIB; COMBINATION; CYTARABINE; RELAPSE; HLA;
D O I：
10.1097/MPH.0000000000000672
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Sorafenib is a promising agent for treating pediatric refractory acute myeloid leukemia (AML) exhibiting FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD); however, its optimal use needs to be established. We report 2 cases of refractory pediatric FLT3-ITD-positive AML treated with sorafenib. Case 1 underwent stem cell transplantation (SCT) without entering remission, despite the use of chemotherapy. This patient relapsed despite receiving post-SCT sorafenib. Chemotherapy combined with sorafenib successfully achieved complete remission in case 2. This patient received post-SCT sorafenib and remains in complete remission. The combination of pre-SCT and post-SCT sorafenib may thus be effective for pediatric refractory FLT3-ITD-positive AML.
引用
收藏
页码：E199 / E202
页数：4
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