Ni-Catalyzed Direct Reductive Amidation via C-O Bond Cleavage

被引：128
|
作者：
Correa, Arkaitz [1 ]
Martin, Ruben [1 ,2 ]
机构：
[1] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain
[2] Catalan Inst Res & Adv Studies ICREA, Barcelona 08010, Spain
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 20期
基金：
欧洲研究理事会;
关键词：
UNACTIVATED ALKYL BROMIDES; CROSS-COUPLING REACTIONS; ARYL HALIDES; DIRECT CARBOXYLATION; OXIDATIVE AMIDATION; BENZYL HALIDES; ISOCYANATES; ALDEHYDES; ELECTROPHILES; REACTIVITY;
D O I：
10.1021/ja5029793
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel Ni-catalyzed reductive amidation of C(sp(2))-O and C(sp(3))-O electrophiles with isocyanates is described. This umpolung reaction allows for an unconventional preparation of benzamides using simple starting materials and easy-to-handle Ni catalysts.
引用
收藏
页码：7253 / 7256
页数：4
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