Notch2 signaling contributes to cell growth, invasion, and migration in salivary adenoid cystic carcinoma

被引:20
|
作者
Qu, Jing [1 ]
Song, Min [1 ]
Xie, Jian [1 ]
Huang, Xiao-Yu [1 ]
Hu, Xiao-Meng [1 ]
Gan, Rui-Huan [1 ]
Zhao, Yong [2 ]
Lin, Li-Song [3 ]
Chen, Jiang [4 ]
Lin, Xu [5 ]
Zheng, Da-Li [5 ]
Lu, You-Guang [1 ]
机构
[1] Fujian Med Univ, Affiliated Stomatol Hosp, Dept Prevent Dent, Fuzhou 350002, Fujian, Peoples R China
[2] Fujian Med Univ, Affiliated Stomatol Hosp, Dept Pathol, Fuzhou 350002, Fujian, Peoples R China
[3] Fujian Med Univ, Dept Oral & Maxillofacial Surg, Affiliated Hosp 1, Fuzhou 350005, Fujian, Peoples R China
[4] Fujian Med Univ, Affiliated Stomatol Hosp, Ctr Dent Implant, Fuzhou 350002, Fujian, Peoples R China
[5] Fujian Med Univ, Sch Basic Med Sci, Key Lab, Minist Educ Gastrointestinal Canc, Fuzhou 350108, Peoples R China
关键词
Notch2; Salivary adenoid cystic carcinoma; Proliferation; Migration; Invasion; DIFFERENTIAL EXPRESSION; THERAPEUTIC TARGET; GENES; METASTASIS; INHIBITION; ACTIVATION; PATHWAY;
D O I
10.1007/s11010-015-2575-z
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Many studies have explored whether the Notch signaling pathway has a tumor-suppressive or an oncogenic role in various tumors; however, the role of the Notch signaling pathway in salivary adenoid cystic carcinoma (SACC) is still unknown. In this study, we attempt to define the role of Notch2 signaling in cell growth, invasion, and migration in SACC. We compared Notch2 expression in clinical SACC samples with that of normal samples by using immunohistochemical staining. Then, we down-regulated Notch2 expression to observe the effect of Notch2 on proliferation, invasion, migration, and the expression of known target genes of Notch signal pathway. According to our results, Notch2 expression was higher in SACC tissues compared with normal tissues. Knockdown of Notch2 inhibited cell proliferation, invasion, and migration in vitro and down-regulated the expression of HEY2 and CCND1. The results of this study suggest that Notch2 has an essential role in the cell growth, invasion, and migration of SACC. Notch2 may therefore be a potential target gene for the treatment of SACC by interfering with cell growth and metastasis.
引用
收藏
页码:135 / 141
页数:7
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