Modulating TNF-α signaling with natural products

被引：100
|
作者：
Paul, Atish T. [1 ]
Gohil, Vikrantsinh M. [1 ]
Bhutani, Kamlesh K. [1 ]
机构：
[1] Natl Inst Pharmaceut Educ & Res, Dept Nat Prod, Sector 67, SAS, Nagar 160062, Punjab, India
来源：
DRUG DISCOVERY TODAY | 2006年 / 11卷 / 15-16期
关键词：
D O I：
10.1016/j.drudis.2006.06.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Natural products have been, and continue to be, a major source of pharmacologically active substances from which drugs can be developed. Currently, tumor necrosis factor-alpha (TNF-alpha) inhibitors from natural origins are being advanced for the treatment of inflammatory disorders. Elevated TNF-alpha synthesis has been associated with the development of diabetes, septic shock, tumorigenesis, rheumatoid arthritis, psoriatic arthritis and inflammatory bowel disease. Currently, only protein-based drugs are available for the clinical inhibition of TNF-alpha activity. Small-molecule drugs that can regulate TNF-alpha levels or activity might provide a cost-effective alternative to protein-based therapeutics. This review briefly highlights the physiological and pathological roles of TNF-alpha, and covers those natural compounds capable of interfering with TNF-alpha activity.
引用
收藏
页码：725 / 732
页数：8
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