Modulating TNF-α signaling with natural products

被引：100
|
作者：
Paul, Atish T. [1 ]
Gohil, Vikrantsinh M. [1 ]
Bhutani, Kamlesh K. [1 ]
机构：
[1] Natl Inst Pharmaceut Educ & Res, Dept Nat Prod, Sector 67, SAS, Nagar 160062, Punjab, India
来源：
DRUG DISCOVERY TODAY | 2006年 / 11卷 / 15-16期
关键词：
D O I：
10.1016/j.drudis.2006.06.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Natural products have been, and continue to be, a major source of pharmacologically active substances from which drugs can be developed. Currently, tumor necrosis factor-alpha (TNF-alpha) inhibitors from natural origins are being advanced for the treatment of inflammatory disorders. Elevated TNF-alpha synthesis has been associated with the development of diabetes, septic shock, tumorigenesis, rheumatoid arthritis, psoriatic arthritis and inflammatory bowel disease. Currently, only protein-based drugs are available for the clinical inhibition of TNF-alpha activity. Small-molecule drugs that can regulate TNF-alpha levels or activity might provide a cost-effective alternative to protein-based therapeutics. This review briefly highlights the physiological and pathological roles of TNF-alpha, and covers those natural compounds capable of interfering with TNF-alpha activity.
引用
收藏
页码：725 / 732
页数：8
相关论文
共 50 条
  • [1] Iguratimod inhibits osteoclastogenesis by modulating the RANKL and TNF-α signaling pathways
    Li, Chang-hong
    Ma, Zhen-zhen
    Jian, Lei-lei
    Wang, Xin-yu
    Sun, Lin
    Liu, Xiang-yuan
    Yao, Zhong-qiang
    Zhao, Jin-xia
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 90
  • [2] Therapeutic Potential of Natural Products from Terrestrial Plants as TNF-α Antagonist
    Verma, Praveen Kumar
    Bala, Manju
    Kumar, Neeraj
    Singh, Bikram
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2012, 12 (13) : 1422 - 1435
  • [3] Shear madness in TNF-α signaling
    Wagner, DD
    BLOOD, 2003, 102 (08) : 2711 - 2712
  • [4] TNF-α signaling in Fanconi anemia
    Du, Wei
    Erden, Ozlem
    Pang, Qishen
    BLOOD CELLS MOLECULES AND DISEASES, 2014, 52 (01) : 2 - 11
  • [5] TNF-α signaling in glaucomatous neurodegeneration
    Tezel, Guelguen
    GLAUCOMA: AN OPEN WINDOW TO NEURODEGENERATION AND NEUROPROTECTION, 2008, 173 : 409 - 421
  • [6] TNF-α Inhibitors with Anti-Oxidative Stress Activity from Natural Products
    Li, Jing
    Zhang, Huibin
    Huang, Wenlong
    Qian, Hai
    Li, Ying
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2012, 12 (13) : 1408 - 1421
  • [7] Syntheses of Minutuminolate and Related Coumarin Natural Products and Evaluation of Their TNF-α Inhibitory Activities
    Choo, Malcolm Zheng Yuan
    Khaw, Lachelle Wei Ting
    Chai, Christina Li Lin
    ACS OMEGA, 2023, 8 (44): : 41785 - 41791
  • [8] The inhibition of TNF-α-induced NF-κB activation by marine natural products
    Folmer, Florence
    Jaspars, Marcel
    Solano, Godofredo
    Cristofanon, Silvia
    Henry, Estelle
    Tabudravu, Jioji
    Black, Kenny
    Green, David H.
    Kuepper, Frithjof C.
    Aalbersberg, William
    Feussner, Klaus
    Dicato, Mario
    Diederich, Marc
    BIOCHEMICAL PHARMACOLOGY, 2009, 78 (06) : 592 - 606
  • [9] Natural but Not Inducible Regulatory T Cells Require TNF-α Signaling for In Vivo Function
    Housley, William J.
    Adams, Catherine O.
    Nichols, Frank C.
    Puddington, Lynn
    Lingenheld, Elizabeth G.
    Zhu, Li
    Rajan, Thiruchandurai V.
    Clark, Robert B.
    JOURNAL OF IMMUNOLOGY, 2011, 186 (12): : 6779 - 6787
  • [10] Inter-competetion and conversion among TNF-α-induced signaling complexes determine the outcomes of TNF-α signaling
    Yang, Zhang-Hua
    Wu, Xiao-Nan
    Wang, Xuekun
    He, Peng
    Hong, Mao
    Han, Jiahuai
    FASEB JOURNAL, 2016, 30
12345