Self-assembled signaling aptamer DNA arrays for protein detection

被引:129
|
作者
Lin, Chenxiang
Katilius, Evaldas
Liu, Yan
Zhang, Junping
Yan, Hao [1 ]
机构
[1] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA
[2] Arizona State Univ, Biodesign Inst, Tempe, AZ 85287 USA
关键词
DNA arrays; molecular recognition; protein detection; self-assembly; signaling aptamers;
D O I
10.1002/anie.200600438
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
(Chemical Equation Presented) Sticking the tiles: A DNA-tile-directed self-assembly of signaling aptamers into high-density nanoarrays allows subnanomolar detection of protein molecules by using confocal fluorescence microscopy imaging. This water-soluble aptamer microarray provides a novel strategy for developing programmable sensor arrays. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:5296 / 5301
页数:6
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