The American Public Is Ready to Accept Human-Animal Chimera Research

被引：16

作者：

Crane, Andrew T. ^{[1
]}

Shen, Francis X. ^{[2
,3
,4
]}

Brown, Jennifer L. ^{[2
,3
]}

Cormack, Warren ^{[2
]}

Ruiz-Estevez, Mercedes ^{[8
]}

Voth, Joseph P. ^{[1
]}

Sawai, Tsutomu ^{[5
,6
]}

Hatta, Taichi ^{[6
]}

Fujita, Misao ^{[5
,6
]}

Low, Walter C. ^{[1
,3
,7
]}

机构：

[1] Univ Minnesota, Dept Neurosurg, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Sch Law, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Grad Program Neurosci, Minneapolis, MN 55455 USA

[4] Massachusetts Gen Hosp, Ctr Law Brain & Behav, Boston, MA 02114 USA

[5] KUIAS Kyoto Univ, Inst Adv Study Human Biol WPI ASHBi, Kyoto, Japan

[6] Kyoto Univ, Ctr iPS Cell Res & Applicat, Uehiro Res Div iPS Cell Eth, Kyoto, Japan

[7] Univ Minnesota, Stem Cell Inst, Minneapolis, MN USA

[8] Recombinetics Inc, Eagan, MN USA

来源：

STEM CELL REPORTS | 2020年 / 15卷 / 04期

关键词：

AMAZONS MECHANICAL TURK; JAPAN;

D O I：

10.1016/j.stemcr.2020.08.018

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

We report findings from a new survey of US public attitudes toward human-animal chimeric embryo (HACE) research, designed to compare with recently reported Japanese survey data. We find that 59% of the US public can personally accept the process of injecting human induced pluripotent stem cells into genetically modified swine embryos and having human tissues produced in a pig's body transplanted into a human. This is greater acceptance than in Japan, and there is even strong acceptance among those with strong religious affiliations and who self-identify as conservatives. We argue that strong public support for HACE research, as well as the emerging literature suggesting that humanization of research animals is very unlikely, should compel the NIH to lift its current moratorium on HACE research.

引用

页码：804 / 810

页数：7

共 50 条

[1] Response to the ISSCR guidelines on human-animal chimera research
Koplin, Julian J.
BIOETHICS, 2023, 37 (02) : 192 - 198
[2] Rethinking the oversight conditions of human-animal chimera research
Piotrowska, Monika
BIOETHICS, 2021, 35 (01) : 98 - 104
[3] BIOETHICS NIH plans to fund human-animal chimera research
Kaiser, Jocelyn
SCIENCE, 2016, 353 (6300) : 634 - 635
[4] Public Attitudes toward Human-Animal Chimera Research May Be More Complicated than They Appear
Bolo, Isabel
Wills, Ben Curran
Maschke, Karen J.
STEM CELL REPORTS, 2021, 16 (02): : 225 - 226
[5] The changing landscape of human-animal chimera research: A Canadian regulatory perspective
Bordet, Sylvie
Bennett, Jami
Knoppers, Bartha Maria
McNagny, Kelly M.
STEM CELL RESEARCH, 2010, 4 (01) : 10 - 16
[6] A Technological and Regulatory Review on Human-Animal Chimera Research: The Current Landscape of Biology, Law, and Public Opinion
Brown, Jennifer L.
Voth, Joseph P.
Person, Kennedy
Low, Walter C.
CELL TRANSPLANTATION, 2023, 32
[7] Ethical arguments concerning human-animal chimera research: a systematic review
Koko Kwisda
Lucie White
Dietmar Hübner
BMC Medical Ethics, 21
[8] Ethical arguments concerning human-animal chimera research: a systematic review
Kwisda, Koko
White, Lucie
Huebner, Dietmar
BMC MEDICAL ETHICS, 2020, 21 (01)
[9] Current Public Support for Human-Animal Chimera Research in Japan Is Limited, Despite High Levels of Scientific Approval
Inoue, Yusuke
Shineha, Ryuma
Yashiro, Yoshimi
CELL STEM CELL, 2016, 19 (02) : 152 - 153
[10] Ethical considerations for human-animal neurological chimera research: mouse models and beyond
Hyun, Insoo
EMBO JOURNAL, 2019, 38 (21):

← 1 2 3 4 5 →