Rhodium(III)-catalyzed synthesis of indoles from 1-alkylidene-2-arylhydrazines and alkynes via C-H and N-N bond cleavages

被引：31
|
作者：
Matsuda, Takanori [1 ]
Tomaru, Yuki [1 ]
机构：
[1] Tokyo Univ Sci, Dept Appl Chem, Shinjuku Ku, Tokyo 1628601, Japan
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 22期
关键词：
Alkyne; Annulation; C-H bond functionalization; Hydrazine; Indole; Rhodium; PALLADIUM-CATALYZED REACTIONS; INTERNAL ALKYNES; OXIDATIVE CYCLIZATION; EFFICIENT SYNTHESIS; DIRECTING GROUP; ARYL ENAMINES; ACTIVATION; FUNCTIONALIZATION; ISOQUINOLINES; ANILINES;
D O I：
10.1016/j.tetlet.2014.04.016
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
1-Alkylidene-2-arylhydrazines undergo annulative coupling with internal alkynes in the presence of a rhodium(III) catalyst and a copper(II) salt. The reaction proceeds through cleavage of the C-H and N-N bonds of hydrazines to afford 1,2,3-trisubstituted indole derivatives. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3302 / 3304
页数：3
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