The role of donor-derived cell-free DNA in the detection of renal allograft injury

被引：10
|
作者：
Zhou, Yang [1 ]
Cheng, Dongrui [2 ]
Jiang, Tingya [3 ]
机构：
[1] Jiangsu Univ, Inst Life Sci, Zhenjiang 212013, Jiangsu, Peoples R China
[2] Jinling Hosp, Natl Clin Res Ctr Kidney Dis, Nanjing 210016, Peoples R China
[3] AlloDx Biotech Co Ltd, Shanghai 201100, Peoples R China
来源：
NEPHROLOGIE & THERAPEUTIQUE | 2021年 / 17卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Damage types; Donor-derived free DNA; Infect; Noninvasive rejection detection; Renal allograft injury; DELAYED GRAFT FUNCTION; NUCLEOSOME FOOTPRINT; ACUTE REJECTION; TRANSPLANT; PHENOTYPES; INFECTION; REVEALS; RISK;
D O I：
10.1016/j.nephro.2020.10.003
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Donor-derived cell-free DNA refers to the cell-free DNA derived from apoptosis or necrosis of allograft tissue, circulating in the body fluids of patients after organ transplantation, and carries health information on the donor tissue. In the past two years, donor-derived cell-free DNA has rapidly become a research hotspot in the field of graft rejection detection after organ transplant. Recent published data have increased our understanding of donor-derived cell-free DNA in the field of kidney transplantation, especially in association with acute rejection. Donor-derived cell-free DNA is predicted to become the next-generation biomarker for the non-invasive detection of allograft rejection. This article reviews the research, involving donor-derived cell-free DNA in ischemia-reperfusion injury, delayed graft function, acute rejection (antibody mediated rejection and T-cell mediated rejection), and BK virus nephropathy. We further discuss the limitations of current research models and suggest directions for future study. (C) 2020 Societe francophone de nephrologie, dialyse et transplantation. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：12 / 17
页数：6
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