Tumor cell specific and lysosome-targeted delivery of nitric oxide for enhanced photodynamic therapy triggered by 808 nm near-infrared light

被引：144
|
作者：
Xiang, Hui-Jing [1 ,2 ]
Deng, Qiao [1 ,2 ]
An, Lu [3 ,4 ]
Guo, Min [1 ,2 ]
Yang, Shi-Ping [3 ,4 ]
Liu, Jin-Gang [1 ,2 ]
机构：
[1] E China Univ Sci & Technol, Key Lab Adv Mat MOE, Shanghai 200237, Peoples R China
[2] E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China
[3] Shanghai Normal Univ, Key Lab Resource Chem MOE, Shanghai 200234, Peoples R China
[4] Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, Shanghai 200234, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 01期
关键词：
NANOPLATFORM; NITROSYL;
D O I：
10.1039/c5cc07006f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel cancer cell lysosome-targetable multifunctional NO-delivery nanoplatform(Lyso-Ru-NO@FA@C-TiO2) (1) was developed. It selectively targets folate-receptor overexpressed cancer cells and specifically locates within the lysosome organelle to which NO and reactive oxygen species are simultaneously released upon 808 nm NIR light irradiation. The dual-targeted nanoplatform (1) demonstrated the highest anticancer efficacy compared with nontargeted counterparts under NIR light sensitization.
引用
收藏
页码：148 / 151
页数：4
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