Conformationally rigid trifluoromethyl-substituted α-amino acid designed for peptide structure analysis by solid-state 19F NMR spectroscopy

被引：95

作者：

Mikhailiuk, Pavel K.

Afonin, Sergii

Chernega, Alerander N.

Rusanov, Eduard B.

Platonov, Maxini O.

Dubinina, Galina G.

Berditsch, Marina

UIrich, Anne S.

Komarov, Igor V.

机构：

[1] Univ Karlsruhe, Inst Organ Chem, D-76133 Karlsruhe, Germany

[2] Kyiv Natl Taras Shvchenko Univ, Dept Chem, UA-01033 Kiev, Ukraine

[3] Enamine Ltd, UA-01103 Kiev, Ukraine

[4] NAS Ukraine, Inst Organ Chem, UA-02094 Kiev, Ukraine

[5] Inst Biol Grenzflachen, Forschungszentrum Karlsruhe, D-76344 Eggenstein Leopoldshafen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 34期

关键词：

amino acids; fluorine; membrane-active peptides; NMR spectroscopy;

D O I：

10.1002/anie.200600346

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Designing a sturdy label: The fluorinated amino acid L-CF3-Bpg (see picture), which was specifically designed as a 19F NMR label for structure analysis of membrane-bound peptides, does not display the drawbacks of previously used labels. The amino acid can be readily incorporated into peptides and is particularly suitable as a substitute for Leu, Ile, and Met. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5659 / 5661

页数：3

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