pH-Triggered Release from Polyamide Microcapsules Prepared by Interfacial Polymerization of a Simple Diester Monomer

The majority of current pH-triggered release systems is designed to respond to either low or high pH. Encapsulants based on polyanipholytes are an example of materials that can respond to both acidic and basic pH However, polyampholyte-based encapsulants generally possess a low loading capacity and have difficulty retaining their small-molecule cargo. The current work utilizes interfacial polymerization between polyamines and a pyromellitic diester diacid chloride to form high capacity "liquid core shell" polyamide microcapsules that are stable in a dry or nonpolar environment but undergo steady, controlled release at pH 7.4 and accelerated release at pH 5 and pH 10. The rate of release can be tuned by adjusting the amine cross-linker feed ratio, which varies the degree of cross-linking in the polymer shell. The thinshell microcapsule exhibited suitable barrier properties and tunable dual acid/base-triggered release, with applications in a wide range of pH environments.