Comparison of artesunate and chloroquine activities against Plasmodium vivax gametocytes

被引：14
|
作者：
Nacher, M
Silachamroon, U
Singhasivanon, P
Wilairatana, P
Phumratanaprapin, W
Fontanet, A
Looareesuwan, S
机构：
[1] Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Bangkok, Thailand
[2] Inst Pasteur, Unite Rech & Expertise Epidemiol Malad Emergentes, Paris, France
[3] Shoklo Malaria Res Unit, Mae Sot, Thailand
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 07期
关键词：
D O I：
10.1128/AAC.48.7.2751-2752.2004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The gametocidal activities of chloroquine and artesunate were compared. The relative risk (RR) of having detectable gametocytes appear after treatment initiation was lower in artesunate-treated patients (n = 792) than in chloroquine-treated patients (n = 695) (RR = 0.29; 95% CI = 0.2 to 0.40; P < 0.0001). The duration and magnitude of gametocyte carriage were also lower for artesunate than chloroquine. By reducing the transmission of Plasmodium vivax to the vector, artesunate could therefore reduce the incidence of P. vivax malaria.
引用
收藏
页码：2751 / 2752
页数：2
相关论文
共 50 条
  • [31] INFECTIVITY OF GAMETOCYTES OF PLASMODIUM-FALCIPARUM AND PLASMODIUM-VIVAX AFTER STORAGE INVITRO
    SOMBOON, P
    MORAKOTE, N
    ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1990, 84 (01): : 89 - 91
  • [32] Therapeutic efficacies of artesunate-sulfadoxine-pyrimethamine and chloroquine-sulfadoxine-pyrimethamine in vivax malaria pilot studies:: Relationship to Plasmodium vivax dhfr mutations
    Tjitra, E
    Baker, J
    Suprianto, S
    Cheng, Q
    Anstey, NM
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (12) : 3947 - 3953
  • [33] THE EFFECT OF PYRIMETHAMINE (DARAPRIM) ON THE GAMETOCYTES AND OOCYSTS OF PLASMODIUM-FALCIPARUM AND PLASMODIUM-VIVAX
    SHUTE, PG
    MARYON, M
    TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1954, 48 (01) : 50 - &
  • [34] WR 238605, chloroquine, and their combinations as blood schizonticides against a chloroquine-resistant strain of Plasmodium vivax in Aotus monkeys
    Obaldia, N
    Rossan, RN
    Cooper, RD
    Kyle, DE
    Nuzum, EO
    Rieckmann, KH
    Shanks, GD
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1997, 56 (05): : 508 - 510
  • [35] Short-term effect of chloroquine on the infectivity of Plasmodium chabaudi gametocytes
    Gautret, P
    Voza, T
    Chabaud, AG
    Landau, I
    PARASITE, 2001, 8 (04) : 363 - 367
  • [36] INVITRO ACTIVITY OF CHLOROQUINE ON THE INFECTIVITY OF PLASMODIUM-BERGHEI ANKA GAMETOCYTES
    SAID, A
    WERY, M
    ANNALES DE LA SOCIETE BELGE DE MEDECINE TROPICALE, 1989, 69 (03): : 209 - 211
  • [37] An in vitro system for assessing the sensitivity of Plasmodium vivax to chloroquine
    Tasanor, O
    Noedl, H
    Na-Bangchang, K
    Congpuong, K
    Sirichaisinthop, J
    Wernsdorfer, WH
    ACTA TROPICA, 2002, 83 (01) : 49 - 61
  • [38] Efficacy of chloroquine in the treatment of Plasmodium vivax malaria in Turkey
    Kurcer, MA
    Simsek, Z
    Zeyrek, FY
    Atay, S
    Çelik, H
    Kat, I
    Topluoglu, S
    ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 2004, 98 (05): : 447 - 451
  • [39] Chloroquine-resistant Plasmodium vivax, Brazilian Amazon
    Filho, Franklin Simoes de Santana
    Arcanjo, Ana Ruth de Lima
    Chehuan, Yonne Melo
    Costa, Monica Regina
    Martinez-Espinosa, Flor Ernestina
    Vieira, Jose Luis
    Vale Barbosa, Maria das Gragas
    Alecrim, Wilson Duarte
    Alecrim, Maria das Gragas Costa
    EMERGING INFECTIOUS DISEASES, 2007, 13 (07) : 1125 - 1126
  • [40] Confirmed Plasmodium vivax Resistance to Chloroquine in Central Vietnam
    Pham Vinh Thanh
    Nguyen Van Hong
    Nguyen Van Van
    Louisa, Melva
    Baird, Kevin
    Nguyen Xuan Xa
    Grietens, Koen Peeters
    Le Xuan Hung
    Tran Thanh Duong
    Rosanas-Urgell, Anna
    Speybroeck, Niko
    D'Alessandro, Umberto
    Erhart, Annette
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (12) : 7411 - 7419
12345