Reaction of 2-oxoindolin-3-ylidene derivatives with heterocyclic enamines, a convenient one-pot synthesis of pyrimido [5,4:5′,6′]pyrido[2,3-b]indole-2, 4-dione and spiro indolin-2-one-3, 5′-pyrido [2,3-d] pyrimidines

被引：6

作者：

El-Ahl, AAS ^{[1
]}

机构：

[1] Mansoura Univ, Dept Chem, Fac Sci, Mansoura, Egypt

来源：

SYNTHETIC COMMUNICATIONS | 2000年 / 30卷 / 12期

关键词：

D O I：

10.1080/00397910008087401

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of 6-aminouracils 2a, b with 2-oxoindolin-3-ylideneacetophenones la-h afforded Pyrimido[5,4:5', 6'] pyrido-[2, 3-b] indole- 2, 4-diones 3 a-k via a regiospecific Michael addition, followed by cyclization, Alternatively, the reaction of 2a with 2-oxoindolin-3-ylidenemalononitriles 6a, b gave rise to regiospecific formation of spiro indolin-2-one-3, 5'-pyrido[2,3-d]pyrimidines 7a,b.

引用

页码：2223 / 2231

页数：9

共 50 条

[21] Synthesis of Derivatives of Cyclopenta[4',5']Pyrido-[3',2':4,5]Thieno[3,2-d]Pyrimidines and Pyrimido[5',4':2,3]-Thieno[2,3-c]Isoquinolines
Paronikyan, E. G.
Dashyan, Sh. Sh.
Noravyan, A. S.
Minasyan, N. S.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2014, 50 (08) : 1188 - 1194
[22] Sodium Formate-Catalyzed One-Pot Synthesis of Functionalized Spiro[indoline-3,5′-pyrido[2,3-d]pyrimidine]/Spiro[acenaphthylene-1,5′-pyrido[2,3-d]-pyrimidine] Derivatives
Nurjamal, Khondekar
Brahmachari, Goutam
CHEMISTRYSELECT, 2019, 4 (08): : 2363 - 2367
[23] Synthesis and anticonvulsant activity of pyrano[4′,3′:4,5] pyrido[2,3-b]thieno[3,2-d] pyrimidine derivatives and pyrimido[5′, 4′:2,3]-thieno[2,3-c]isoquinoline derivatives
Paronikyan E.G.
Noravyan A.S.
Akopyan Sh.F.
Dzhagatspanyan I.A.
Nazaryan I.M.
Paronikyan R.G.
Pharmaceutical Chemistry Journal, 2007, 41 (9) : 466 - 469
[24] A one-pot microwave-assisted synthesis of pyrido[2,3-d]pyrimidines
NÚria Mont
Jordi Teixidó
C. Oliver Kappe
José I. Borrell
Molecular Diversity, 2003, 7 : 153 - 159
[25] A one-pot microwave-assisted synthesis of pyrido[2,3-d]pyrimidines
Mont, Nuria
Teixido, Jordi
Kappe, C. Oliver
Borrell, Jose I.
MOLECULAR DIVERSITY, 2003, 7 (2-4) : 153 - 159
[26] Reactions of α-thiocarboxamidocinnamonitrile derivatives with diethyl malonate:: Synthesis of pyrazolo-[3,4-b]-α-pyridinone, thieno[2,3-b]-α-pyridinone, pyrido[2,3:4′,5′]thieno[2,3-c]pyridazine and pyrido[2,3:4′,5′]thieno[2,3-d]pyrimidinonethione derivatives
Attaby, FA
Eldin, SM
Abou-Abdou, MB
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1997, 129 : 121 - 133
[27] A READY ENTRY TO SUBSTITUTED DERIVATIVES OF PYRIDO[3'',2''/4',5']THIENO[2',3'/5,6]PYRIDO[2,3-D]-PYRIMIDINES, A NEW TETRAHETEROCYCLIC RING-SYSTEM
PEINADOR, C
VEIGA, MC
OJEA, V
QUINTELA, JM
HETEROCYCLES, 1994, 38 (09) : 2065 - 2072
[28] Reactions with pyridinethione derivatives:: Synthesis and characterization of thienyl[2,3-b]pyridine, pyrido[2′,3′:4,5] thieno[2,3-b]pyridazine, pyrido[2′,3′:4,5] thieno[2,3-b]-pyrimidinone, pyrazolino[3′,4′:4,5] thieno[2,3-b]pyridine and aminopyrazolo[3,4-b]pyridine derivatives
Attaby, FA
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1997, 126 : 27 - 38
[29] Synthesis of pyrido[2′,3′:4,5]thieno[2,3-d]pyrimidines through Friedlander reactions
Abdel-Mohsen, Shawkat A.
Geies, Ahmed A.
JOURNAL OF CHEMICAL RESEARCH, 2007, (12) : 689 - 692
[30] PYRIDO[2,3-D]PYRIMIDINES .7. REACTIONS WITH 1,3-DIMETHYL-5,7-DICHLORO-6-NITROPYRIDO[2,3-D]PYRIMIDIN-2,4-DIONE AMINES - SYNTHESIS OF TRIAZOLO(4',5'/4,5)PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES
BUROVA, OA
SMIRNOVA, NM
SAFONOVA, TS
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1993, (03): : 398 - 401

← 1 2 3 4 5 →