Epithelial-mesenchymal transitions in tumour progression

被引：5479
|
作者：
Thiery, JP [1 ]
机构：
[1] Inst Curie, CNRS, UMR 144, F-75248 Paris 05, France
来源：
NATURE REVIEWS CANCER | 2002年 / 2卷 / 06期
关键词：
D O I：
10.1038/nrc822
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Without epithelial-mesenchymal transitions, in which polarized epithelial cells are converted into motile cells, multicellular organisms would be incapable of getting past the blastula stage of embryonic development. However, this important developmental programme has a more sinister role in tumour progression. Epithelial-mesenchymal transition provides a new basis for understanding the progression of carcinoma towards dedifferentiated and more malignant states.
引用
收藏
页码：442 / 454
页数：13
相关论文
共 50 条
  • [31] Role of Epithelial-Mesenchymal Transition in Tumor Progression
    Gloushankova, N. A.
    Zhitnyak, I. Y.
    Rubtsova, S. N.
    BIOCHEMISTRY-MOSCOW, 2018, 83 (12-13) : 1469 - 1476
  • [32] Role of Epithelial-Mesenchymal Transition in Tumor Progression
    N. A. Gloushankova
    I. Y. Zhitnyak
    S. N. Rubtsova
    Biochemistry (Moscow), 2018, 83 : 1469 - 1476
  • [33] Epithelial-mesenchymal transition in colorectal adenocarcinoma progression
    Shyshkin, M. A.
    Fen, S., V
    ZAPOROZHYE MEDICAL JOURNAL, 2020, 22 (05) : 694 - 700
  • [34] Role of epithelial-mesenchymal transition in tumor progression
    Puisieux, Alain
    BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE, 2009, 193 (09): : 2017 - 2032
  • [35] Epithelial-Mesenchymal Plasticity in Cancer Progression and Metastasis
    Lu, Wei
    Kang, Yibin
    DEVELOPMENTAL CELL, 2019, 49 (03) : 361 - 374
  • [36] Epithelial-mesenchymal, mesenchymal-epithelial, and endothelial-mesenchymal transitions in malignant tumors: An update
    Simona Gurzu
    Sabin Turdean
    Attila Kovecsi
    Anca Otilia Contac
    Ioan Jung
    World Journal of Clinical Cases, 2015, (05) : 393 - 404
  • [37] Epithelial-mesenchymal, mesenchymal-epithelial, and endothelial-mesenchymal transitions in malignant tumors: An update
    Gurzu, Simona
    Turdean, Sabin
    Kovecsi, Attila
    Contac, Anca Otilia
    Jung, Ioan
    WORLD JOURNAL OF CLINICAL CASES, 2015, 3 (05) : 393 - 404
  • [38] Direct evidence for epithelial-mesenchymal transitions in breast cancer
    Trimboli, Anthony J.
    Fukino, Koichi
    de Bruin, Alain
    Wei, Guo
    Shen, Lei
    Tanner, Stephan M.
    Creasap, Nicholas
    Rosol, Thomas J.
    Robinson, Michael L.
    Eng, Charis
    Ostrowski, Michael C.
    Leone, Gustavo
    CANCER RESEARCH, 2008, 68 (03) : 937 - 945
  • [39] The relationship between vasculogenic mimicry and epithelial-mesenchymal transitions
    Liu, Qiqi
    Qiao, Lili
    Liang, Ning
    Xie, Jian
    Zhang, Jingxin
    Deng, Guodong
    Luo, Hui
    Zhang, Jiandong
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2016, 20 (09) : 1761 - 1769
  • [40] Tumor metastasis: A new twist on epithelial-mesenchymal transitions
    Vernon, AE
    LaBonne, C
    CURRENT BIOLOGY, 2004, 14 (17) : R719 - R721
12345