Epithelial-mesenchymal transitions in tumour progression

被引：5479
|
作者：
Thiery, JP [1 ]
机构：
[1] Inst Curie, CNRS, UMR 144, F-75248 Paris 05, France
来源：
NATURE REVIEWS CANCER | 2002年 / 2卷 / 06期
关键词：
D O I：
10.1038/nrc822
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Without epithelial-mesenchymal transitions, in which polarized epithelial cells are converted into motile cells, multicellular organisms would be incapable of getting past the blastula stage of embryonic development. However, this important developmental programme has a more sinister role in tumour progression. Epithelial-mesenchymal transition provides a new basis for understanding the progression of carcinoma towards dedifferentiated and more malignant states.
引用
收藏
页码：442 / 454
页数：13
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