In vitro activity of AZD2563, a novel oxazolidinone, against European Gram-positive cocci

被引：16

作者：

Fluit, AC ^{[1
]}

Schmitz, FJ ^{[1
]}

Verhoef, J ^{[1
]}

Milatovic, D ^{[1
]}

机构：

[1] UMCU, Eijkman Winkler Ctr, NL-3508 GA Utrecht, Netherlands

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2002年 / 50卷 / 02期

关键词：

D O I：

10.1093/jac/dkf109

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

AZD2563 is a new oxazolidinone that has targeted activity against Gram-positive bacteria. The in vitro activity of AZD2563 and nine comparators against 1543 European enterococcal, staphylococcal and streptococcal isolates was determined. The compound is a potent oxazolidinone, with no isolate tested displaying an MIC > 4 mg/L and 94.4% having an MIC less than or equal to2 mg/L. Compared with linezolid, the distribution of MICs for all species of bacteria tested, with the exception of Enterococcus faecium, was shifted by one or two dilution steps to lower values for AZD2563. Thus, this oxazolidinone is a promising new antibiotic for the treatment of infections with Gram-positive cocci.

引用

页码：271 / 276

页数：6

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