Core-shell polymeric nanoparticles comprising BODIPY and fluorescein as ultra-bright ratiometric fluorescent pH sensors

被引：8
|
作者：
Grazon, Chloe [1 ,3 ]
Si, Yang [1 ]
Placial, Jean-Pierre [1 ]
Rieger, Jutta [2 ]
Meallet-Renault, Rachel [1 ,4 ]
Clavier, Gilles [1 ]
机构：
[1] Univ Paris Saclay, CNRS, ENS Cachan, PPSM, F-94235 Cachan, France
[2] Sorbonne Univ, CNRS, UMR 8232, Inst Parisien Chim Mol,Team Chim Polymeres, F-75005 Paris, France
[3] Univ Bordeaux, CNRS, UMR 5629, Bordeaux INP,LCPO, F-33607 Pessac, France
[4] Univ Paris Saclay, Univ Paris Sud, CNRS, ISMO, F-91405 Orsay, France
来源：
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES | 2019年 / 18卷 / 05期
关键词：
RADICAL POLYMERIZATION; SILICA NANOPARTICLES; ENERGY-TRANSFER; EMISSION; DESIGN; DYES; MICELLES; PROBES; TOOLS;
D O I：
10.1039/c8pp00457a
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new ratiometric fluorescent pH nanosensor is presented. It is based on ultrabright nanoparticles containing two spatially separated fluorophores: BODIPY covalently linked to the polystyrene core and fluorescein grafted to the nanoparticle shell. The nanoparticles comprise a large number (>= 2500) of both fluorescent moieties. Their spectroscopic characteristics were studied at different pH and ionic strength. They could successfully be used to determine the solution pH between 5.5 and 7.5 by measuring the fluorescence intensity ratio of the sensor molecule (fluorescein) relative to the reference dye (BODIPY).
引用
收藏
页码：1156 / 1165
页数：10
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