Testican 3 expression in adult T-cell leukemia

被引：15
|
作者：
Kamioka, Mikio [1 ]
Imamura, Jun [2 ]
Komatsu, Naoki [3 ]
Daibata, Masanori [3 ]
Sugiura, Tetsuro [1 ]
机构：
[1] Kochi Univ, Dept Lab Med, Kochi 7838505, Japan
[2] Kochi Univ, Dept Transfus Med, Kochi 7838505, Japan
[3] Kochi Univ, Dept Hematol & Resp Med, Kochi 7838505, Japan
来源：
LEUKEMIA RESEARCH | 2009年 / 33卷 / 07期
关键词：
Adult T-cell leukemia; Human T-lymphotropic virus type I; Activating transcriptional factor 3; Testican; 3; VIRUS TYPE-I; ACTIVATING TRANSCRIPTION FACTOR-3; MATRIX METALLOPROTEINASES; ANTIBODIES; GENE; ATF3; SUPPRESSION; INDUCER; EMMPRIN; DISEASE;
D O I：
10.1016/j.leukres.2008.11.006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Adult T-cell leukemia (ATL) is an aggressive disease characterized by visceral invasion, and ATL regulates matrix metalloproteinase (MMP) activities of the endothelial cells. The controlling system of MMP activities in ATL is regulated by various factors such as Emmprin and tissue inhibitor of MMP. In this study, we demonstrated that Testican 3 expression in ATL decreased the activity of MMP. Furthermore, we showed that the expression of Testican 3 was regulated by activating transcriptional factor 3 in human T-lymphotropic virus type I-related cell lines. Thus, Testican 3 is a novel regulator to reduce the activity of MMP in ATL (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：913 / 918
页数：6
相关论文
共 50 条
  • [21] BIOPSY OF ADULT T-CELL LEUKEMIA
    KIKUCHI, M
    MITSUI, T
    EIMOTO, T
    TOYOOKA, R
    NISHIUCHI, M
    GANN MONOGRAPH ON CANCER RESEARCH, 1982, (28): : 37 - 50
  • [22] Adult T-cell leukemia/lymphoma
    Oliveira, Pedro Dantas
    Farre, Lourdes
    Bittencourt, Achilea Lisboa
    REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, 2016, 62 (07): : 691 - 700
  • [23] Adult T-cell leukemia/lymphoma
    Setoyama, M
    Tanaka, A
    Katahira, Y
    Kanzaki, T
    DERMATOLOGY AT THE MILLENNIUM, 1999, : 731 - 733
  • [24] Leukemogenesis of Adult T-Cell Leukemia
    Jun-ichirou Yasunaga
    Masao Matsuoka
    International Journal of Hematology, 2003, 78 : 312 - 320
  • [25] FAMILIAL ADULT T-CELL LEUKEMIA
    MIYAMOTO, Y
    YAMAGUCHI, K
    NISHIMURA, H
    TAKATSUKI, K
    MOTOORI, T
    MORIMATSU, M
    YASAKA, T
    OHYA, I
    KOGA, T
    CANCER, 1985, 55 (01) : 181 - 185
  • [26] Adult T-cell leukemia/lymphoma
    Bittencourt, Achilea L.
    Farre, Lourdes
    ANAIS BRASILEIROS DE DERMATOLOGIA, 2008, 83 (04) : 351 - 359
  • [27] Adult T-Cell Leukemia/Lymphoma
    Mehta-Shah, Neha
    Ratner, Lee
    Horwitz, Steven M.
    JOURNAL OF ONCOLOGY PRACTICE, 2017, 13 (08) : 487 - +
  • [28] ADULT T-CELL LEUKEMIA IN SPOUSES
    SANADA, I
    YAMAGUCHI, K
    YOSHIDA, M
    ISHII, T
    TSUKAMOTO, A
    SATO, M
    OBATA, S
    SHIDO, T
    JAPANESE JOURNAL OF CANCER RESEARCH, 1989, 80 (05): : 401 - 404
  • [29] Retinoid and Adult T-Cell Leukemia
    Maeda, Y.
    Kanamaru, A.
    Sasakawa, A.
    Hirase, C.
    Morita, J.
    Niki, K.
    Furukawa, K.
    Yamaguchi, T.
    Morita, Y.
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2009, 25 (11) : 1253 - 1253
  • [30] Discovery of adult T-cell leukemia
    Kiyoshi Takatsuki
    Retrovirology, 2
12345