Synthesis of fused thiazolo[3,2-a]pyrimidinones: N-aryl-2chloroacetamides as doubly electrophilic building blocks

被引：7
|
作者：
Banothu, Janardhan [1 ]
Basavoju, Srinivas [1 ]
Bavantula, Rajitha [1 ]
Crooks, Peter A. [2 ]
机构：
[1] Natl Inst Technol, Dept Chem, Warangal 506004, Andhra Pradesh, India
[2] Univ Arkansas Med Sci, Coll Pharm, Dept Pharmaceut Sci, Little Rock, AR 72205 USA
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 01期
关键词：
Thiazolo[3,2-alpyrimidinones; 2-Chloro-N-phenylacetamide N-(Benzo[d]thiazol-2-y1)-2-; chloroacetamide; Single crystal X-ray analysis; DERIVATIVES; THIAZOLOPYRIMIDINES; PYRIMIDINE;
D O I：
10.1016/j.tetlet.2013.11.001
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-Chloro-N-phenylacetamide and N-(benzo[d]thiazol-2-y1)-2-chloroacetamide are doubly electrophilic building blocks for the formation of ring annulated thiazolo[3,2-a]pyrimidinone products. This synthetic route involves formation of the title compound in acceptable product yields by the elimination of the by-product, aniline/2-aminobenzothiazole. Analytical and spectral studies, as well as single crystal X-ray data on the representative compound 6c confirmed the structure of all the reaction products. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：224 / 226
页数：3
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