Synthesis of fused thiazolo[3,2-a]pyrimidinones: N-aryl-2chloroacetamides as doubly electrophilic building blocks

被引：7

作者：

Banothu, Janardhan ^{[1
]}

Basavoju, Srinivas ^{[1
]}

Bavantula, Rajitha ^{[1
]}

Crooks, Peter A. ^{[2
]}

机构：

[1] Natl Inst Technol, Dept Chem, Warangal 506004, Andhra Pradesh, India

[2] Univ Arkansas Med Sci, Coll Pharm, Dept Pharmaceut Sci, Little Rock, AR 72205 USA

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 01期

关键词：

Thiazolo[3,2-alpyrimidinones; 2-Chloro-N-phenylacetamide N-(Benzo[d]thiazol-2-y1)-2-; chloroacetamide; Single crystal X-ray analysis; DERIVATIVES; THIAZOLOPYRIMIDINES; PYRIMIDINE;

D O I：

10.1016/j.tetlet.2013.11.001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Chloro-N-phenylacetamide and N-(benzo[d]thiazol-2-y1)-2-chloroacetamide are doubly electrophilic building blocks for the formation of ring annulated thiazolo[3,2-a]pyrimidinone products. This synthetic route involves formation of the title compound in acceptable product yields by the elimination of the by-product, aniline/2-aminobenzothiazole. Analytical and spectral studies, as well as single crystal X-ray data on the representative compound 6c confirmed the structure of all the reaction products. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：224 / 226

页数：3

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