AN EFFICIENT SINGLE STEP SYNTHESIS OF PYRIDAZINE, PYRAZOLO[5,1-c]-1,2,4-TRIAZINE, 1,2,4-TRIAZOLO[5,1-c]-1,2,4-TRIAZINE AND 1,2,4-TRIAZINO[4,3-a]BENZIMIDAZOLE DERIVATIVES

被引：24
|
作者：
Shaaban, Mohamed R. [1 ]
Saleh, Tamer S. [1 ]
Farag, Ahmad M. [1 ]
机构：
[1] Cairo Univ, Fac Sci, Dept Chem, Giza 12613, Egypt
来源：
HETEROCYCLES | 2009年 / 78卷 / 03期
关键词：
POTENTIAL ANXIOLYTIC AGENTS; BENZIMIDAZOLES; ANTAGONISTS; RESISTANCE;
D O I：
10.3987/COM-08-11559
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Coupling of E-1-(1-methylbenzimidazol-2-yl)-3-(N,N-dimethylamino)prop-2-enone (1) with the arenediazonium salt gave hydrazonopropanal 5 which underwent cyclocondensation with active methylene compounds to afford substituted pyridazin-6-imine 8 and 11. The enaminone 1 coupled also with the diazonium salts prepared from aminopyrazole, aminotriazole and 2-amino-1H-benzimidazole to afford pyrazolo[5,1-c]-1,2,4-triazine 15, 1,2,4-triazolo[5,1-c]-1,2,4-triazine 19, 1,2,4-triazino[4,3-a]benzimidazole 23 derivatives, respectively.
引用
收藏
页码：699 / 706
页数：8
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