Bradykinin increases the secretion and expression of endothelin-1 through kinin B2 receptors in melanoma cells

被引：23

作者：

Andoh, Tsugunobu ^{[1
]}

Akira, Ahmad ^{[1
]}

Saiki, Ikuo ^{[2
]}

Kuraishi, Yasushi ^{[1
]}

机构：

[1] Toyama Univ, Dept Appl Pharmacol, Grad Sch Med & Pharmaceut Sci, Toyama 9300194, Japan

[2] Toyama Univ, Dept Pathogen Biochem, Inst Nat Med, Toyama 9300194, Japan

来源：

PEPTIDES | 2010年 / 31卷 / 02期

关键词：

Bradykinin; Kinin B-2 receptor; Endothelin-1; Melanoma cell; PROTEIN-KINASE-C; NF-KAPPA-B; NEUTRAL ENDOPEPTIDASE; CANCER PAIN; TUMOR; IDENTIFICATION; TARGETS; CLONING; GROWTH; MODEL;

D O I：

10.1016/j.peptides.2009.12.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study was conducted to determine whether bradykinin would affect the secretion and expression of endothelin-1 (ET-1) in B16-BL6 melanoma cells. Bradykinin administered to cultured melanoma cells increased preproET-l mRNA level and the secretion of ET-1. Although kinin B-1 and B-2 receptor mRNAs are expressed in the melanoma cells, the increase of preproET-1 mRNA expression and the secretion of ET-1 were inhibited by kinin B-2, but not by B-1, receptor antagonist. These results suggest that bradykinin regulates the secretion and biosynthesis of ET-1 through kinin B-2 receptor in tumor cells. especially melanoma cells. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：238 / 241

页数：4

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