Bradykinin increases the secretion and expression of endothelin-1 through kinin B2 receptors in melanoma cells

被引：23
|
作者：
Andoh, Tsugunobu [1 ]
Akira, Ahmad [1 ]
Saiki, Ikuo [2 ]
Kuraishi, Yasushi [1 ]
机构：
[1] Toyama Univ, Dept Appl Pharmacol, Grad Sch Med & Pharmaceut Sci, Toyama 9300194, Japan
[2] Toyama Univ, Dept Pathogen Biochem, Inst Nat Med, Toyama 9300194, Japan
来源：
PEPTIDES | 2010年 / 31卷 / 02期
关键词：
Bradykinin; Kinin B-2 receptor; Endothelin-1; Melanoma cell; PROTEIN-KINASE-C; NF-KAPPA-B; NEUTRAL ENDOPEPTIDASE; CANCER PAIN; TUMOR; IDENTIFICATION; TARGETS; CLONING; GROWTH; MODEL;
D O I：
10.1016/j.peptides.2009.12.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The present study was conducted to determine whether bradykinin would affect the secretion and expression of endothelin-1 (ET-1) in B16-BL6 melanoma cells. Bradykinin administered to cultured melanoma cells increased preproET-l mRNA level and the secretion of ET-1. Although kinin B-1 and B-2 receptor mRNAs are expressed in the melanoma cells, the increase of preproET-1 mRNA expression and the secretion of ET-1 were inhibited by kinin B-2, but not by B-1, receptor antagonist. These results suggest that bradykinin regulates the secretion and biosynthesis of ET-1 through kinin B-2 receptor in tumor cells. especially melanoma cells. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：238 / 241
页数：4
相关论文
共 50 条
  • [1] Regulation of kinin B2 receptors by bradykinin in human lung cells
    Bengtson, Sara H.
    Eddleston, Jane
    Morgelin, Matthias
    Zuraw, Bruce L.
    Herwald, Heiko
    BIOLOGICAL CHEMISTRY, 2008, 389 (11) : 1435 - 1440
  • [2] CAPTOPRIL INHIBITS ENDOTHELIN-1 SECRETION FROM ENDOTHELIAL-CELLS THROUGH BRADYKININ
    MOMOSE, N
    FUKUO, K
    MORIMOTO, S
    OGIHARA, T
    HYPERTENSION, 1993, 21 (06) : 921 - 924
  • [3] Twisting integrin receptors increases endothelin-1 gene expression in endothelial cells
    Chen, JX
    Fabry, B
    Schiffrin, EL
    Wang, N
    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2001, 280 (06): : C1475 - C1484
  • [4] Bradykinin specificity and signaling at GPR100 and B2 kinin receptors
    Leeb-Lundberg, LMF
    BRITISH JOURNAL OF PHARMACOLOGY, 2004, 143 (08) : 931 - 932
  • [5] Expression of the bradykinin B1 and B2 receptors in human airway epithelial cells.
    Eddleston, J
    Fox, AJ
    Lim, S
    Donnelly, LE
    Newton, R
    Haddad, EB
    Chung, KF
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 159 (03) : A180 - A180
  • [6] Expression of bradykinin B2 receptors in human phagocytes
    Stüwe, S
    Böckmann, S
    Paegelow, I
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1998, 357 (04) : R15 - R15
  • [7] Endogenous bradykinin activates ischaemically sensitive cardiac visceral afferents through kinin B2 receptors in cats
    Tjen-A-Looi, SC
    Pan, HL
    Longhurst, JC
    JOURNAL OF PHYSIOLOGY-LONDON, 1998, 510 (02): : 633 - 641
  • [8] Stable expression of rat bradykinin B1 and B2 receptors in HEK-293 cells
    Ueno, A
    Naraba, H
    Kosugi, Y
    Yoshimura, M
    Oh-ishi, S
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1998, 358 (01) : R336 - R336
  • [9] Expression of endothelin-1 and endothelin receptors in cultured human glioblastoma cells
    Sone, M
    Takahashi, K
    Totsune, K
    Murakami, O
    Arihara, Z
    Satoh, F
    Mouri, T
    Shibahara, S
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2000, 36 : S390 - S392
  • [10] Functional expression of kinin B1 and B2 receptors in mouse abdominal aorta
    Felipe, S. A.
    Rodrigues, E. S.
    Martin, R. P.
    Paiva, A. C. M.
    Pesquero, J. B.
    Shimuta, S. I.
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2007, 40 (05) : 649 - 655
12345