VIP in the rat parotid gland in response to irradiation

被引：10
|
作者：
Hockerfelt, U
Kjorell, U
Malm, V
Henriksson, R
Franzen, L
Forsgren, S
机构：
[1] UMEA UNIV,DEPT ANAT,S-90187 UMEA,SWEDEN
[2] UMEA UNIV,DEPT ONCOL,S-90185 UMEA,SWEDEN
来源：
REGULATORY PEPTIDES | 1997年 / 68卷 / 02期
关键词：
vasoactive intestinal polypeptide; neuropeptides; substance P; immunohistochemistry; radioimmunoassay;
D O I：
10.1016/S0167-0115(96)02107-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In the present study, the immunohistochemical expression of vasoactive intestinal polypeptide (VIP) in the parotid gland of rats exposed to fractionated irradiation was examined. VIP concentration was analyzed by radioimmunoassay (RIA). Irradiation lead to a marked increase in the immunohistochemical expression of VIP in the innervation of the gland parenchyme. VIP-like immunoreactivity (LI) frequently coexisted with SP (substance P)-LI in these nerve fibers. The pattern of VIP-innervation in association with large ducts and blood vessel walls was unchanged. RIA analysis revealed a more than three-fold elevation in VIP content in the gland in response to irradiation. The increase in VIP immunoreaction and VIP content was seen at examination ten days after cessation of a five-day treatment with a total dose of 30-40 Gray. The upregulation of VIP may be related to changes in the production of neurotrophic factors and to an increased demand for a potentiation of secretagogue effects of SP. (C) 1997 Elsevier Science B.V.
引用
收藏
页码：83 / 89
页数：7
相关论文
共 50 条
  • [21] ULTRASTRUCTURAL INJURY FOLLOWING X-IRRADIATION OF RAT PAROTID-GLAND ACINAR CELLS
    PRATT, NE
    SODICOFF, M
    ARCHIVES OF ORAL BIOLOGY, 1972, 17 (08) : 1177 - &
  • [22] SECRETORY RESPONSE OF PAROTID GLAND TO ISOPROTERNOL
    SIMSON, JA
    ANATOMICAL RECORD, 1968, 160 (02): : 429 - &
  • [23] THE CO-LOCALIZATION OF SUBSTANCE-P AND VIP IN CHOLINERGIC-TYPE TERMINALS OF THE RAT PAROTID-GLAND
    ALHADITHI, BAK
    STAUBER, V
    MITCHELL, J
    JOURNAL OF ANATOMY, 1988, 159 : 83 - 92
  • [24] EFFECTS OF IRRADIATION OF PAROTID GLAND AND PANCREAS ON HUMAN ISOAMYLASES
    WOLF, RO
    TAYLOR, LL
    BRACE, K
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1970, 54 (02) : 214 - &
  • [25] Parotid Gland as an Organ-at-Risk for Craniospinal Irradiation
    King, M.
    Modlin, L. A.
    Million, L.
    Donaldson, S.
    Gibbs, I. C.
    Soltys, S. G.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 84 (03): : S634 - S634
  • [26] The Parotid Gland is an Underrecognized Organ at Risk for Craniospinal Irradiation
    King, Martin T.
    Modlin, Leslie
    Million, Lynn
    Donaldson, Sarah S.
    Gibbs, Iris C.
    Choi, Clara Y. H.
    Soltys, Scott G.
    TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2016, 15 (03) : 472 - 479
  • [27] IRRADIATION OF MALIGNANT-TUMORS OF THE PAROTID-GLAND
    VIRAVATHANA, T
    PREMPREE, T
    SCOTT, RM
    ACTA RADIOLOGICA ONCOLOGY, 1981, 20 (02): : 75 - 80
  • [28] NEW INSIGHTS IN THE VASCULAR SUPPLY OF THE HUMAN PAROTID GLAND-CONSEQUENCES FOR PAROTID GLAND-SPARING IRRADIATION
    van Holten, Marjolein J.
    Roesink, Judith M.
    Terhaard, Chris H. J.
    Braam, Petra M.
    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2010, 32 (07): : 837 - 843
  • [29] NEUROPEPTIDES AND DISUSE OF THE RAT PAROTID-GLAND
    MANSSON, B
    EKMAN, R
    HAKANSON, R
    EKSTROM, J
    EXPERIMENTAL PHYSIOLOGY, 1990, 75 (04) : 597 - 599
  • [30] Insulin gene expression in the rat parotid gland
    Kalis, K
    Han, JM
    Kim, SK
    JOURNAL OF DENTAL RESEARCH, 1996, 75 : 1462 - 1462
12345