VIP in the rat parotid gland in response to irradiation

被引：10
|
作者：
Hockerfelt, U
Kjorell, U
Malm, V
Henriksson, R
Franzen, L
Forsgren, S
机构：
[1] UMEA UNIV,DEPT ANAT,S-90187 UMEA,SWEDEN
[2] UMEA UNIV,DEPT ONCOL,S-90185 UMEA,SWEDEN
来源：
REGULATORY PEPTIDES | 1997年 / 68卷 / 02期
关键词：
vasoactive intestinal polypeptide; neuropeptides; substance P; immunohistochemistry; radioimmunoassay;
D O I：
10.1016/S0167-0115(96)02107-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In the present study, the immunohistochemical expression of vasoactive intestinal polypeptide (VIP) in the parotid gland of rats exposed to fractionated irradiation was examined. VIP concentration was analyzed by radioimmunoassay (RIA). Irradiation lead to a marked increase in the immunohistochemical expression of VIP in the innervation of the gland parenchyme. VIP-like immunoreactivity (LI) frequently coexisted with SP (substance P)-LI in these nerve fibers. The pattern of VIP-innervation in association with large ducts and blood vessel walls was unchanged. RIA analysis revealed a more than three-fold elevation in VIP content in the gland in response to irradiation. The increase in VIP immunoreaction and VIP content was seen at examination ten days after cessation of a five-day treatment with a total dose of 30-40 Gray. The upregulation of VIP may be related to changes in the production of neurotrophic factors and to an increased demand for a potentiation of secretagogue effects of SP. (C) 1997 Elsevier Science B.V.
引用
收藏
页码：83 / 89
页数：7
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