The Effects of Loranthus parasiticus on Scopolamine-Induced Memory Impairment in Mice

被引：9
|
作者：
Weon, Jin Bae [1 ]
Lee, Jiwoo [1 ]
Eom, Min Rye [1 ]
Jung, Youn Sik [1 ]
Ma, Choong Je [1 ,2 ]
机构：
[1] Kangwon Natl Univ, Dept Med Biomat Engn, Coll Biomed Sci, Chunchon 200701, South Korea
[2] Kangwon Natl Univ, Biotechnol Res Inst, Chunchon 200701, South Korea
来源：
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2014年 / 2014卷
关键词：
ALZHEIMERS-DISEASE; OXIDATIVE STRESS; NG108-15; CELLS; GLUTAMATE; RAT; NEURONS; DAMAGE; BRAIN; NEUROTOXICITY; INHIBITION;
D O I：
10.1155/2014/860180
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
This study is undertaken to evaluate cognitive enhancing effect and neuroprotective effect of Loranthus parasiticus. Cognitive enhancing effect of Loranthus parasiticus was investigated on scopolamine-induced amnesia model in Morris water maze test and passive avoidance test. We also examined the neuroprotective effect on glutamate-induced cell death in HT22 cells by MTT assay. These results of Morris water maze test and passive avoidance test indicated that 10 and 50mg/kg of Loranthus parasiticus reversed scopolamine-induced memory deficits. Loranthus parasiticus also protected against glutamate-induced cytotoxicity in HT22 cells. As a result of in vitro test for elucidating possible mechanism, Loranthus parasiticus inhibited AChE activity, ROS production, and Ca2+ accumulation. Loranthus parasiticus showed memory enhancing effect and neuroprotective effect and these effects may be related to inhibition of AChE activity, ROS level, and Ca2+ influx.
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页数：7
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