Synthesis of a Benzannulated Pyrrolizidine by a Copper-Catalyzed Intramolecular α-Arylation Reaction

被引：2

作者：

Araujo, Flavia Magalhaes ^{[1
]}

Ventura, Wellington Martins ^{[1
]}

Taylor, Jason Guy ^{[1
]}

机构：

[1] Univ Fed Ouro Preto, ICEB, Dept Quim, Campus Univ Morro do Cruzeiro, BR-35400000 Ouro Preto, MG, Brazil

来源：

HELVETICA CHIMICA ACTA | 2014年 / 97卷 / 04期

关键词：

Pyrrolo[1,2-a]indole; alpha-Arylation; Aza-Michael reaction; Cyclization reactions; CYCLIZATION;

D O I：

10.1002/hlca.201300313

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A synthetic route to the pyrrolo[1,2-a]indole ring system (benzannulated pyrrolizidine) involving a base-induced intramolecular aza-Michael reaction as the key C-N bond-forming penultimate step, followed by a Cu-catalyzed intramolecular alpha-arylation reaction, to provide the tricyclic framework over six steps is described.

引用

页码：569 / 573

页数：5

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