Cytochrome P450 2D6 activity in human liver microsomes: Assessment of drug metabolizing enzyme lability as a function of incubation conditions

被引:0
|
作者
Foti, RS [1 ]
Fisher, MB [1 ]
机构
[1] Pfizer Inc, Pfizer Global Res & Dev, Discovery Pharmacokinet Dynam & Metab, Groton, CT 06340 USA
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
204
引用
收藏
页码:102 / 102
页数:1
相关论文
共 50 条
  • [41] Human liver microsomes study on the inhibitory effect of plantainoside D on the activity of cytochrome P450 activity
    Zhou, Jin
    Qian, Xian
    Zhou, Yanqing
    Xiong, Shili
    Ji, Shuxia
    Wang, Ying
    Zhao, Ping
    BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2022, 22 (01)
  • [42] Human liver microsomes study on the inhibitory effect of plantainoside D on the activity of cytochrome P450 activity
    Jin Zhou
    Xian Qian
    Yanqing Zhou
    Shili Xiong
    Shuxia Ji
    Ying Wang
    Ping Zhao
    BMC Complementary Medicine and Therapies, 22
  • [43] The role of cytochrome P450 2D6 in the metabolism of moclobemide
    Hartter, S
    Dingemanse, J
    Baier, D
    Ziegler, G
    Hiemke, C
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 1996, 6 (03) : 225 - 230
  • [44] Substrate Specificity, Inhibitors and Regulation of Human Cytochrome P450 2D6 and Implications in Drug Development
    Zhou, Shu-Feng
    Liu, Jun-Ping
    Lai, Xin-Sheng
    CURRENT MEDICINAL CHEMISTRY, 2009, 16 (21) : 2661 - 2805
  • [45] Cytochrome P450 2D6 and treatment of codeine dependence
    Romach, MK
    Otton, SV
    Somer, G
    Tyndale, RF
    Sellers, EM
    JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2000, 20 (01) : 43 - 45
  • [46] Cytochrome P450 2D6 polymorphism and character traits
    Suzuki, E
    Kitao, Y
    Ono, Y
    Iijima, Y
    Inada, T
    PSYCHIATRIC GENETICS, 2003, 13 (02) : 111 - 113
  • [47] Only truncated, not complete cytochrome P450 2D6 RNA transcript and no detectable enzyme activity are expressed in human lymphocytes
    Mcconnachie, LA
    Phillips, B
    Bajpai, M
    Shen, DD
    Ho, RJY
    DRUG METABOLISM AND DISPOSITION, 2003, 31 (09) : 1103 - 1107
  • [48] Cytochrome P450 2D6 SNP array for individual drug response optimization
    Ku, L
    Shen, L
    Sun, H
    Bush-Donovan, C
    CLINICAL CHEMISTRY, 2005, 51 : A182 - A182
  • [49] The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6
    Desta, Z
    Wu, GM
    Morocho, AM
    Flockhart, DA
    DRUG METABOLISM AND DISPOSITION, 2002, 30 (03) : 336 - 343
  • [50] Activity of human p450 2D6 in biphasic solvent systems
    Zhao, Jin
    Tan, Elaine
    Ferras, Julian
    Auclair, Karine
    BIOTECHNOLOGY AND BIOENGINEERING, 2007, 98 (02) : 508 - 513