PREPARATION AND CHARACTERIZATION OF ZINC COMPLEXES AND EVALUATION OF THEIR ANTIMICROBIAL ACTIVITY

被引：0
|
作者：
Skalickova, Sylvie [1 ,3 ]
Kopel, Pavel [1 ,3 ]
Cihalova, Kristyna [1 ,3 ]
Nejdl, Lukas [1 ,3 ]
Melros, Rodrigo Miguel Angel [1 ,3 ]
Sladek, Zbysek [2 ]
Kizek, Rene [1 ,3 ]
机构：
[1] Mendel Univ Brno, Dept Chem & Biochem, Brno 61300, Czech Republic
[2] Mendel Univ Brno, Dept Morphol Physiol & Anim Genet, Brno 61300, Czech Republic
[3] Brno Univ Technol, Cent European Inst Technol, CZ-61600 Brno, Czech Republic
来源：
MENDELNET 2015 | 2015年
关键词：
Zinc; EDTA; nitriloacetic acid; spectrophotometry; antimicrobial activity;
D O I：
暂无
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
Zinc chelates with diethylenetriaminepentaacetic acid (DTPA), ethylenediaminetetraacetic acid (EDTA), nitrilotriacetic acid (NTA) and iminodiacetic acid (IDA) have been prepared and conditions for Zn2+ release have been studied. The prepared Zn2+ chelate complexes are of following compositions: ZnCl2(EDTA), Zn(ClO4)(2) . 6H(2)O (EDTA), ZnCl2(NTA), ZnCl2(NTA)(3)(btc), Zn(ClO4)(2) . 6H(2)O (NTA), ZnCl2 (NDA), Zn(ClO4)(2) . 6H(2)O (NDA), ZnCl2(NDA)(3)(btc). (H(3)btc = 1,3,5-benzenetricarboxylic acid). All variants of Zn2+ complexes were diluted to the concentration range 0-1420 mu M and the absorbance spectra in the range of 230-330 nm were measured. The antimicrobial properties of Zn2+ complexes were studied by the method of the growth curves of the bacteria cultures Staphyloccocus aureus. The 50% inhibitory concentration was determined to 500 mu M of each Zn2+ complex. It has been found that the Zn2+ complexes showed increased antimicrobial effect on Staphyloccocus aureus.
引用
收藏
页码：595 / 599
页数：5
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