Efficacy of chemoradiotherapy with low-dose cisplatin and continuous infusion of 5-fluorouracil for unresectable squamous cell carcinoma of the esophagus

被引：8
|
作者：
Takagawa, Ryo [1 ]
Kunisaki, Chikara [2 ]
Makino, Hirochika [2 ]
Kosaka, Takashi
Ono, Hidetaka A.
Akiyama, Hirotoshi
Shimada, Hiroshi
机构：
[1] Yokohama City Univ, Grad Sch Med, Dept Surg Gastroenterol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan
[2] Yokohama City Univ, Gastroenterol Ctr, Dept Surg, Yokohama, Kanagawa 2360004, Japan
来源：
DISEASES OF THE ESOPHAGUS | 2009年 / 22卷 / 06期
关键词：
chemoradiotherapy; C-reactive protein; esophageal cancer; low-dose chemotherapy; unresectable esophageal cancer; DEFINITIVE CHEMORADIOTHERAPY; CONCURRENT CHEMORADIOTHERAPY; PROGNOSTIC-FACTORS; RADIATION-THERAPY; PHASE-II; CANCER; TRIAL; RADIOTHERAPY; SURVIVAL;
D O I：
10.1111/j.1442-2050.2008.00935.x
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
P>We retrospectively investigated the efficacy of a chemoradiotherapy regimen using daily low-dose cisplatin and continuous 5-fluorouracil infusion in 71 registered patients with unresectable esophageal cancer. The overall response rate (complete response plus partial response) was 59%. The major toxicities observed were leukopenia and anorexia. The 1- and 3-year overall survival rates were 54.6% and 18.4%, respectively. A low preoperative C-reactive protein level was found to be associated with a good response. The pretreatment performance status and response results were both shown to be prognostic factors for overall survival. These findings confirmed that the chemoradiotherapy regimen had curative potential for unresectable esophageal cancer.
引用
收藏
页码：482 / 489
页数：8
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