Physico-chemical characterisation of a new polymorph of caffeine

被引：29

作者：

Dichi, Emma ^{[1
]}

Legendre, Bernard ^{[1
]}

Sghaier, Mehrez ^{[1
]}

机构：

[1] Univ Paris Sud, Fac Pharm, EA 401, F-92296 Chatenay Malabry, France

来源：

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2014年 / 115卷 / 02期

关键词：

Caffeine; Sublimation; Polymorph; (T; P) unary phase diagram; RAY-POWDER-DIFFRACTION; ANHYDROUS CAFFEINE; VAPOR-PRESSURE; X-RAY; THERMODYNAMIC PROPERTIES; CRYSTAL-STRUCTURE; THERMAL-ANALYSIS; SCANNING TRANSITIOMETRY; MOLECULAR-CRYSTALS; HYDRATE;

D O I：

10.1007/s10973-013-3429-0

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

Caffeine is a widely used drug substance. Two polymorphic forms and one hydrate of caffeine are known. Thanks to scanning transitiometry, the curves pressure versus temperature, P = f(T), of the caffeine were plotted. A (temperature, pressure) unary phase diagram was deduced. It confirms the existence of a new polymorph of caffeine at low pressure synthesized by sublimation. Its identification and its physico-chemical properties were determined using a variety of experimental methods: X-ray powder diffraction, differential scanning calorimeter, thermogravimetric analysis, thermally stimulated current and electrochemical impedance.

引用

页码：1551 / 1561

页数：11

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