Physico-chemical characterisation of a new polymorph of caffeine

被引：29
|
作者：
Dichi, Emma [1 ]
Legendre, Bernard [1 ]
Sghaier, Mehrez [1 ]
机构：
[1] Univ Paris Sud, Fac Pharm, EA 401, F-92296 Chatenay Malabry, France
来源：
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2014年 / 115卷 / 02期
关键词：
Caffeine; Sublimation; Polymorph; (T; P) unary phase diagram; RAY-POWDER-DIFFRACTION; ANHYDROUS CAFFEINE; VAPOR-PRESSURE; X-RAY; THERMODYNAMIC PROPERTIES; CRYSTAL-STRUCTURE; THERMAL-ANALYSIS; SCANNING TRANSITIOMETRY; MOLECULAR-CRYSTALS; HYDRATE;
D O I：
10.1007/s10973-013-3429-0
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
Caffeine is a widely used drug substance. Two polymorphic forms and one hydrate of caffeine are known. Thanks to scanning transitiometry, the curves pressure versus temperature, P = f(T), of the caffeine were plotted. A (temperature, pressure) unary phase diagram was deduced. It confirms the existence of a new polymorph of caffeine at low pressure synthesized by sublimation. Its identification and its physico-chemical properties were determined using a variety of experimental methods: X-ray powder diffraction, differential scanning calorimeter, thermogravimetric analysis, thermally stimulated current and electrochemical impedance.
引用
收藏
页码：1551 / 1561
页数：11
相关论文
共 50 条
  • [1] Physico-chemical characterisation of a new polymorph of caffeine
    Emma Dichi
    Bernard Legendre
    Mehrez Sghaier
    Journal of Thermal Analysis and Calorimetry, 2014, 115 : 1551 - 1561
  • [2] Physico-chemical characterisation of sago starch
    Centre for Water Soluble Polymers, N. E. Wales Inst., Plas Coch, M., Wrexham, United Kingdom
    不详
    Carbohydr Polym, 4 (361-370):
  • [3] Physico-chemical characterisation of sage starch
    Ahmad, FB
    Williams, PA
    Doublier, JL
    Durand, S
    Buleon, A
    CARBOHYDRATE POLYMERS, 1999, 38 (04) : 361 - 370
  • [4] Production and physico-chemical characterisation of nanoparticles
    Isfort, C. Schulze
    Rochnia, M.
    TOXICOLOGY LETTERS, 2009, 186 (03) : 148 - 151
  • [5] Physico-Chemical Characterisation of Four New Spanish Pomegranate Clones
    Melgarejo-Sanchez, P.
    Hernandez, Fca.
    Martinez, J. J.
    Legua, P.
    Martinez, R.
    Melgarejo, P.
    III INTERNATIONAL SYMPOSIUM ON POMEGRANATE AND MINOR MEDITERRANEAN FRUITS, 2015, 1089 : 319 - 325
  • [6] A physico-chemical characterisation of new raw materials for microcrystalline cellulose manufacturing
    Virtanen, Tommi
    Svedstrom, Kirsi
    Andersson, Seppo
    Tervala, Laura
    Torkkeli, Mika
    Knaapila, Matti
    Kotelnikova, Nina
    Maunu, Sirkka Liisa
    Serimaa, Ritva
    CELLULOSE, 2012, 19 (01) : 219 - 235
  • [7] A physico-chemical characterisation of new raw materials for microcrystalline cellulose manufacturing
    Tommi Virtanen
    Kirsi Svedström
    Seppo Andersson
    Laura Tervala
    Mika Torkkeli
    Matti Knaapila
    Nina Kotelnikova
    Sirkka Liisa Maunu
    Ritva Serimaa
    Cellulose, 2012, 19 : 219 - 235
  • [8] Physico-chemical characterisation of silicon carbide refractories
    Gazulla, M. F.
    Gomez, M. P.
    Orduna, A.
    Barba, A.
    JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, 2006, 26 (15) : 3451 - 3458
  • [9] Physico-chemical characterisation of Indian biomass ashes
    Umantaheswaran, K.
    Batra, Vidya S.
    FUEL, 2008, 87 (06) : 628 - 638
  • [10] Complete physico-chemical characterisation of foundry waste
    Aissaoui, Chahinez
    Diliberto, Cecile
    Mechling, Jean-Michel
    Aranda, Lionel
    ENVIRONMENTAL TECHNOLOGY, 2025, 46 (03) : 336 - 348
12345